Doctor Profile

Wissam Ibrahim Khalife

Wissam Khalife

UTMB Health
301 University Boulevard, JSA 5.106
Galveston, TX 77555


Texas (TX)

Contact Contact Wissam Ibrahim Khalife
T: 409-772-1533
F: 409-772-4982

Cardiology; Internal Medicine


Internal Medicine

Languages Spoken: English, Arabic

Published In:

Texas Super Doctors 2023
Texas Super Doctors 2022
Texas Super Doctors 2021
Texas Rising Stars 2014

About Wissam Khalife

Medical School: Beirut, University of

Graduation Year: 1999

Professional Webpage:

Honors and Awards:

  • Paul Dudley White Cardiology Award, 2022. Presented by Top 100 Registry Business Leaders & Professionals for outstanding achievement and continuous contributions.
  • Texas Super Doctors 2021 selected by Super Doctors. Super Doctors identifies top doctors as selected by their peers and the independent research of MSP Communications. In selecting physicians for Super Doctors, MSP Communications employs a rigorous multi-step process designed to identify physicians who have attained a high degree of peer recognition and professional achievement. Approximately 5% of the physicians within the respective state or region are named to Super Doctors.
  • Doctor of the Year, 2021. Presented by Top 100 Registry Business Leaders & Professionals in recognition of outstanding efforts and achievements in the field of Cardiology.
  • Patient Preferred Cardiologist, 2021. Presented by Patient Preferred Physicians and Practitioners (PPP).
  • Best Doctors in America. Selected by peers to 2019-2020 Best Doctors in America list. “Being named a Best Doctors physician is an honor, and the result of an extensive, impartial, nationwide, peer-physician poll.”
  • Top Heart Failure /Transplant Cardiologist for 2019. Chosen by Top Doctor Awards Magazine. “Each featured Doctor has been selected for their unwavering devotion to the medical field and to their patients. Their credibility as a Top Doctor ensures patients that they have the skill and experience to deserve such a title in their field”.
  • Recognized as a top Cardiologist in Texas by The Leading Physician of the World (LPW) and was included in the 2017 edition of the LPW (2017).
  • Texas Rising Stars 2014 selected by Super Doctors.

Professional Activity:

- Director of Advanced Heart Failure, Transplant and LVAD Program at UTMB.


Director, General Cardiology Fellowship Program at UTMB

Publications, Lectures and Presentations:


  1. Comparison of Coronary Artery Involvement and Mortality in STEMI Patients With and Without SARS-CoV-2 During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis. Thakker RA, Elbadawi A, Chatila KF, Goel SS, Reynoso D, Berbarie RF, Gilani S, Rangasetty U, Khalife W. Curr Probl Cardiol. 2022 Mar;47(3):101032. doi: 10.1016/j.cpcardiol.2021.101032. Epub 2021 Oct 28.PMID: 
  2. Safety of Transcatheter Aortic Valve Replacement in Patients with Aortic Aneurysm: A Propensity Matched Analysis. Justin K. Ugwu, Jideofor K. Ndulue, Khaled A. Sherif, Samson Alliu, Ayman Elbadawi, Tuncay Taskesen, Doha Hussein, Judith N, Ugwu Erugo. Khaled Chatila, Ahmed Almustafa, Wissam I. Khalife, Paul N. Kumfa. Cardiol Ther(March 6, 2022).
  3. Coronary Microvascular Disease. Thakker RA, Rodriguez Lozano J, Rodriguez Lozano P, Motiwala A, Rangasetty U, Khalife W, Chatila K. Cardiol Ther. 2022 Jan 7. doi: 10.1007/s40119-021-00250-6. Online ahead of print. PMID: 34993903
  4. Clinical Characteristics and Outcomes in Immune Checkpoint Inhibitor Therapy-Associated Myocarditis. Thakker RA, Lee MA, Albaeni A, Elbadawi A, Suthar KH, Perez C, Sonstein LK, Farr NM, Venkatesan R, Khalife W, Berbarie RF, Chatila KF. Cardiol Res. 2021 Oct;12(5):270-278. doi: 10.14740/cr1319. Epub 2021 Sep 29.PMID: 
  5. Outcomes in Hospitalization in Patients with Heart Failure Undergoing Remote Pulmonary Artery Pressure Monitoring: A Systematic Review and Meta-Analysis of Major Trials. Thakker RA, Abu-Jazar D, Cabello R, Pham C, Hong J, Abdelmaseih R, Elbadawi A, Albaeni A, Hasan SM, Almustafa A, Murrieta JI, Modi S, Berbarie RF, Khalife W, Chatila KF. Curr Probl Cardiol. 2021 Sep 20:100980. doi: 10.1016/j.cpcardiol.2021.100980. Online ahead of print. PMID: 34547344
  6. Coronary Artery Disease and Aspirin Intolerance: Background And insights on Current Management. Ravi A. Thakker, Leonardo Salazar, Deaa Abu jazar,Pooja Bhakta, Bryan Baker, Chandani Patel, Ayman Elbadawi, Mayank Agarwal, Aiham Albaeni, Mohammed Saleh, Jonathan Esclovan, Danielle El Haddad, Hashim Alwash, Poonam Velagapudi, Ankur Kalra, Sachin Goel, Robert Jay Widmer, Khaled Chatila, Wissam Khalife, Afaq Motiwala, Jennifer McCracken, Hani Jneid, Syed Gilani. Cardiology and Therapy. February 1st, 2022. 
  7. Use of Coronary Intravascular Lithotripsy: A Comprehensive Review of Literature.Jazar DA, Thakker R, Salehin S, Hasan SM, Jabri A, Albaeni A, Addasi Y, Gandhi S, Gilani S, Motiwala A, Khalife W. Curr Probl Cardiol. 2021 Nov 27:101076. doi: 10.1016/j.cpcardiol.2021.101076. Online ahead of print.PMID: 34843807 Review.
  8. COVID-19 Infection and Incidence of Myocarditis: A Multi-Site Population-Based Propensity Score-Matched Analysis. Shivani Priyadarshni, Jordan Westra, Yong-Fang Kuo, Jacques Baillargeon, Wissam Khalife, Mukaila Raji. Cureus, Feb, 2022.  
  9. Accurate Estimation of Right-Filling Pressure Using Handheld Ultrasound Score in Patients with Heart Failure. Albaeni A, Sharma M, Ahmad M, Khalife WI. Am J Med. 2021 Dec 31:S0002-9343(21)00849-4. doi: 10.1016/j.amjmed.2021.11.020. Online ahead of print.PMID: 
  10. Role of Pocket Ultrasound in Assessing Intravascular Volume to Guide Management in Heart Failure Patients with Renal Impairment. Khalife WI, Mukku VK, Albaeni A, Esclovon J, Elbadawi A, Almahmoud MF. Cardiol Ther. 2021 Dec;10(2):491-500. doi: 10.1007/s40119-021-00229-3. Epub 2021 Jun 26. PMID: 
  11. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators.N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27. PMID: 34449189Clinical Trial.
  12. Percutaneous Mitral Valve Repair in Cardiac Amyloidosis and Severe Mitral Regurgitation. Thakker RA, Elbadawi A, Albaeni A, Hasan SM, Suthar KH, Modi SA, Berbarie RF, Khalife W, Chatila KF. Curr Probl Cardiol. 2021 May 3:100881. doi: 10.1016/j.cpcardiol.2021.100881. Online ahead of print. PMID: 
  13. The Burden of Hospitalizations for Vaccine-Preventable Infections in Heart Transplant Recipients. Dang A, Khaled Soufi M, Nguyen C, Orndorff J, Baliss M, Berbarie RF, Khalife WI. Am J Cardiol. 2021 Oct 15;157:148-150. doi: 10.1016/j.amjcard.2021.07.010. Epub 2021 Aug 7. PMID: 
  14. Outcomes With sGC Therapy in Patients With HFpEF: A Meta-Analysis of Prior Trials. Thakker RA, Elbadawi A, Albaeni A, Perez C, Hasan SM, Murrieta JI, Almustafa A, Duarte A, Berbarie RF, Chatila KF, Khalife W. Curr Probl Cardiol. 2021 Jul 4:100924. doi: 10.1016/j.cpcardiol.2021.100924. Online ahead of print.PMID: 
  15. Age-specific trends and outcomes of hospitalizations with acute heart failure in the United States. Elbadawi A, Dang A, Elgendy IY, Thakker R, Albaeni A, Omer MA, Mohamed AH, Gilani S, Chatila K, Khalife WI, Almustafa A. Int J Cardiol. 2021 May 1;330:98-105. doi: 10.1016/j.ijcard.2021.02.031. Epub 2021 Feb 17. PMID: 
  16. Trends and Outcomes of Transcatheter Valve Implantation in Patients With Prior Mediastinal Radiation. Elbadawi A, Elgendy IY, Albaeni A, Aly A, Almustafa A, Shahin HI, Chatterjee A, Alkhouli M, Khalife W, Kapadia S, Jneid H. Am J Cardiol. 2021 Mar 15;143:167-168. doi: 10.1016/j.amjcard.2021.01.003. Epub 2021 Jan 14.PMID: 33453171.
  17. In-Hospital acute ischemic stroke following ST-elevation myocardial infarction. Albaeni A, Harris CM, Nasser H, Sifontes S, Hasan SM, Guduru S, Abusaada K, Chatila K, Gilani S, Khalife WI. Int J Cardiol Heart Vasc. 2020 Dec 10;31:100684. doi: 10.1016/j.ijcha.2020.100684. eCollection 2020 Dec. PMID: 
  18. Transcatheter Edge-to-Edge Repair With MitraClip in Systolic Heart Failure With Ischemic Versus Nonischemic Cardiomyopathy. Elbadawi A, Elgendy IY, Tan BE, Saleh M, Khalife WI, Bhimaraj A, Kapadia SR, Kleiman NS, Goel SS. JACC Cardiovasc Interv. 2020 Dec 14;13(23):2818-2819. doi: 10.1016/j.jcin.2020.09.027. PMID: 
  19. Single Anti-platelet Versus Dual Anti-platelet Therapy After Transcatheter Aortic Valve Implantation: A Meta-Analysis of Randomized Trials. Elbadawi A, Thakker R, Abuzaid AA, Khalife W, Goel SS, Gilani S, Alasnag M, Elgendy IY. Am J Cardiol. 2021 Feb 1;140:152-154. doi: 10.1016/j.amjcard.2020.11.002. Epub 2020 Nov 19. PMID: 
  20. Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Adams KF, Anand I, Arias-Mendoza A, Biering-Sørensen T, Böhm M, Bonderman D, Cleland JGF, Corbalan R, Crespo-Leiro MG, Dahlström U, Echeverria LE, Fang JC, Filippatos G, Fonseca C, Goncalvesova E, Goudev AR, Howlett JG, Lanfear DE, Li J, Lund M, Macdonald P, Mareev V, Momomura SI, O'Meara E, Parkhomenko A, Ponikowski P, Ramires FJA, Serpytis P, Sliwa K, Spinar J, Suter TM, Tomcsanyi J, Vandekerckhove H, Vinereanu D, Voors AA, Yilmaz MB, Zannad F, Sharpsten L, Legg JC, Varin C, Honarpour N, Abbasi SA, Malik FI, Kurtz CE; GALACTIC-HF Investigators. N Engl J Med. 2021 Jan 14;384(2):105-116. doi: 10.1056/NEJMoa2025797. Epub 2020 Nov 13. PMID:  Clinical Trial.
  21. Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Prior Mediastinal Radiation. Elbadawi A, Albaeni A, Elgendy IY, Ogunbayo GO, Jimenez E, Cornwell L, Chatterjee A, Khalife W, Alkhouli M, Kapadia SR, Jneid H. JACC Cardiovasc Interv. 2020 Nov 23;13(22):2658-2666. doi: 10.1016/j.jcin.2020.08.010. PMID: 
  22. Hospital Volume and In-hospital Outcomes with Impella Guided Percutaneous Coronary Interventions: Insights from a National Database. Elbadawi A, Elgendy IY, Omer MA, Khalife W, Mentias A, Ogunbayo GO, Denktas A, Paniagua D, Gilani S, Jneid H. Am J Cardiol. 2020 Jun 1;125(11):1753-1754. doi: 10.1016/j.amjcard.2020.03.007. Epub 2020 Mar 19.PMID: 32279836
  23. Sex Differences in In-Hospital Outcomes of Transcatheter Mitral Valve Repair (from a National Database). Elbadawi A, Elzeneini M, Thakker R, Mahmoud K, Elgendy IY, Megaly M, Hamed M, Omer MA, Chowdhury M, Ogunbayo G, Kamal D, Rangassety U, Jneid H, Gilani S, Khalife W. Am J Cardiol. 2020 May 1;125(9):1391-1397. doi: 10.1016/j.amjcard.2020.01.013. Epub 2020 Feb 8.PMID: 32151434
  24. Temporal Trends and Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Prior Myocardial Infarction. Elbadawi A, Saad M, Elgendy I, Mahmoud K, Barssoum K, Omer M, Mahmoud A, Hamed M, Ogunbayo G, Paniagua D, Khalife W, Jneid H. Structural Heart Journal, Feb 2020, 4(2),115-121.
  25. Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials. Elbadawi A, Omer MA, Elgendy IY, Abuzaid A, Mohamed AH, Rai D, Saad M, Mentias A, Rezq A, Kamal D, Khalife W, London B, Morsy M. Cardiol Ther. 2019 Dec;8(2):365-372. doi: 10.1007/s40119-019-00149-3. Epub 2019 Oct 13.PMID: 
  26. In-hospital left ventricular thrombus following ST-elevation myocardial infarction. Albaeni A, Chatila K, Beydoun HA, Beydoun MA, Morsy M, Khalife WI. Int J Cardiol. 2020 Jan 15;299:1-6. doi: 10.1016/j.ijcard.2019.07.070. Epub 2019 Jul 23.PMID: 
  27. The prognosis of mid-range ejection fraction heart failure: a systematic review and meta-analysis. Altaie S, Khalife W.ESC Heart Fail. 2018 Dec;5(6):1008-1016. doi: 10.1002/ehf2.12353. Epub 2018 Sep 13. PMID: 30211480
  28. Racial Disparities in Type of Heart Failure and Hospitalization. Lee WC, Serag H, Ohsfeldt RL, Eschbach K, Khalife W, Morsy M, Smith KD, Raimer BG. J Immigr Minor Health. 2019 Feb;21(1):98-104. doi: 10.1007/s10903-018-0727-4. PMID: 
  29. Diarrhea-An uncommon presentation of tertiary adrenal insufficiency following heart transplantation. Sikanderkhel S, Choudhry MW, Valentine V, Al-Dossari G, Khalife WI. J Card Surg. 2017 Aug;32(8):522-525. doi: 10.1111/jocs.13175. Epub 2017 Jul 2. PMID: 
  30. Essential Thrombocytosis Mimicking Acute Coronary Syndrome: A Diagnostic Dilemma. Sikanderkhel S, Morsy M, Ridner ML, Khalife WI. Austin J Cardiovasc Dis Atherosclerosis. 2017;4(1):1031.
  31. New Impella Cardiac Power Device Used in Patient with Cardiogenic Shock due to Nonischemic Cardiomyopathy. Cena M, Karam F, Ramineni R, Khalife W, Barbagelata A. Int J Angiol. 2016 Dec;25(4):258-262. doi: 10.1055/s-0034-1384822. Epub 2014 Dec 2. PMID: 
  32. Spontaneous Coronary Artery Dissection: One Disease, Variable Presentations, and Different Management Approaches. Al Emam AR, Almomani A, Gilani SA, Khalife WI. Int J Angiol. 2016 Sep;25(3):139-47. doi: 10.1055/s-0035-1563604. Epub 2015 Sep 14. PMID: 
  33. Influence of Access, Anticoagulant, and Bleeding Definition on Outcomes of Primary Percutaneous Coronary Intervention: Early Experience of an US Academic Center. Bheemarasetti MK, Shawar S, Chithri S, Khalife WI, Rangasetty UM, Fujise K, Gilani SA.Int J Angiol. 2015 Mar;24(1):11-8. doi: 10.1055/s-0034-1394158. PMID: 
  34. The Role of Echocardiography in Heart Failure, Part 1. Kamel Sadat, Massood Ahmad, Qiangiun Cai, Mohamed Morsy, Alejandro Barbagelata, Wissam I. Khalife. Consultant, 2014;54(8):614-617.
  35. The Role of Echocardiography in Heart Failure, Part 2. Kamel Sadat, Masood Ahmad, Qiangjun Cai, Mohamed Morsy, Navin Nanda, Alejandro Barbagelata, Wissam Khalife. 2014; 54(9):693-698.
  36. Park's stitch for a bicuspid aortic valve in a patient on LVAD support. Maoz-Metzl D, Morsy M, Khalife WI, Lick SD. J Card Surg. 2014 Nov;29(6):843-5. doi: 10.1111/jocs.12423. Epub 2014 Aug 7. PMID: 
  37. Acute heart transplant graft failure in association with hyperosmolar hyperglycemia state. Sadat K, Morsy M, Khalife WI. J Card Surg. 2014 Sep;29(5):737-9. doi: 10.1111/jocs.12408. Epub 2014 Jul 19. PMID: 
  38. Reduced coronary blood flow in cardiac tamponade: mystery solved. Abusaid GH, Khalife WI. J Invasive Cardiol. 2012 Dec;24(12):E328-9. PMID: 
  39. Congenital coronary artery fistula presenting later in life. Abusaid GH, Hughes D, Khalife WI, Parto P, Gilani SA, Fujise K. J Cardiol Cases. 2011 Jun 21;4(1):e43-e46. doi: 10.1016/j.jccase.2011.05.008. eCollection 2011 Aug. PMID: 30532867
  40. Heart Disease in Patients with HIV/AIDS-An Emerging Clinical Problem. Gopal M, Bhaskaran A, Khalife WI, Barbagelata A. Curr Cardiol Rev. 2009 May;5(2):149-54.
  41. Hypothyroidism and renal function in patients with systolic heart failure. Merla R, Martinez JD, Martinez MA, Khalife W, Bionat S, Bionat J, Barbagelata A. Tex Heart Inst J. 2010;37(1):66-9. PMID: 
  42. Dilated cardiomyopathy and myocardial infarction secondary to congenital generalized lipodystrophy. Khalife WI, Mourtada MC, Khalil J. Tex Heart Inst J. 2008;35(2):196-9. PMID: 
  43. The TandemHeart pVAD in the treatment of acute fulminant myocarditis. Khalife WI, Kar B.Tex Heart Inst J. 2007;34(2):209-13.PMID: 17622371
  44. Sirolimus-induced alveolar hemorrhage. Khalife WI, Kogoj P, Kar B. J Heart Lung Transplant. 2007 Jun;26(6):652-7. doi: 10.1016/j.healun.2007.02.010. Epub 2007 Apr 16. PMID: 17543794
  45. Idiopathic pure red cell aplasia: case report with review of literature. Khalife W, Murunga E, Mahmoud F.S D J Med. 2005 Dec;58(12):501-5.PMID: 16700352
  46. Treatment of subclinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy. Khalife WI, Tang YD, Kuzman JA, Thomas TA, Anderson BE, Said S, Tille P, Schlenker EH, Gerdes AM. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2409-15. doi: 10.1152/ajpheart.00483.2005. Epub 2005 Jul 15. 
  47. Impending cardiac tamponade as a primary presentation of hypothyroidism: case report and review of literature. Karu AK, Khalife WI, Houser R, VanderWoude J. Endocr Pract. 2005 Jul-Aug;11(4):265-71. doi: 10.4158/EP.11.4.265. PMID:
  48. Microscopic colitis: a report of two cases. Mahmoud F, Khalife W, Elaprolu K, Khurana A. S D J Med. 2005 Apr;58(4):149-53.
  49. Pulmonary lymphangioleiomyomatosis in a postmenopausal woman: case report with review of literature. Khalife WI, Mahmoud F, Larson E, Hardie R. S D J Med. 2005 Apr;58(4):139-43.
  50. Respiratory failure secondary to methemoglobinemia induced by benzocaine: a case report. Khalife WI, Wang R, Khalil J. S D J Med. 2004 Apr;57(4):145-7.

Educational Background:

Board Certified in:

- Advanced Heart Failure and Cardiac Transplant

- Nuclear Cardiology

- Echocardiograpgy

- Cardiovascular disease

- Internal Medicine

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