Doctor Profile

Mark M. Souweidane
MD

Mark Souweidane
MD

Weill Cornell Medicine, Columbia University Medical Center, and NewYork-Presbyterian
525 E 68th Street, Suite 651, Box 99
New York, NY 10005

New York

New York (NY)

Contact Contact Mark M. Souweidane
T: 212-746-2363
F: 212-746-7729

Visit: www.weillcornellbrainandspine.org
Neurological Surgery
Doctor's practice has a pediatric specialty or subspecialty

Neurological Surgery


Profile

Dr. Mark M. Souweidane is nationally recognized in pediatric neurosurgery, with a strong focus in childhood brain tumors. He is regarded as a highly accomplished microneurosurgeon and expert endoscopic surgeon, and is a compassionate advocate for children.

He received his undergraduate degree at the University of Michigan before attending Wayne State University Medical School. His post-graduate residency included a general surgery internship at the University of Michigan Hospitals and a neurosurgery residency at New York University. He completed his training as chief clinical fellow in Pediatric Neurosurgery at the Hospital for Sick Children in Toronto, Canada.

Dr. Souweidane oversees a translational laboratory focusing on improving methods for treating children with incurable brain tumors. His work is nationally regarded for the development of drug delivery techniques for childhood brain tumors that are not amenable to surgical removal. He is the principal investigator (PI) for clinical trials using direct delivery as a novel therapeutic approach. He supplements his laboratory research with clinical projects, both independently and as a member of multi-institutional studies, including the Children’s Oncology Group (COG) and the Pediatric Brain Tumor Consortium (PBTC).

Dr. Souweidane is board-certified by the American Board of Neurological Surgery and the American Board of Pediatric Neurological Surgery. He is a fellow of the American College of Surgeons and the American Academy of Pediatrics. He holds joint appointments at the Memorial Sloan-Kettering Cancer Center and the Hospital for Special Surgery. He serves on the editorial board for Neurosurgery and Journal of Neurosurgery: Pediatrics. He serves as Chairman of the Neurosurgery Committee of the Children’s Oncology Group.

Published In:

New York Super Doctors 2020
New York Super Doctors 2019
New York Super Doctors 2018
New York Super Doctors 2017
New York Super Doctors 2016
New York Super Doctors 2015
New York Super Doctors 2014
New York Super Doctors 2013
New York Super Doctors 2012
New York Super Doctors 2009
New York Super Doctors 2008

About Mark Souweidane

Medical School: Wayne State University School of Medicine

Graduation Year: 1988

Professional Webpage: weillcornell.org/mmsouweidane/

Honors and Awards:

James B. Angell Scholar Recipient,    1982, 1983

Bachelors of Science Degree with High Honors,    1983

Medical Doctorate Degree with Distinction,    1988

Alpha Omega Alpha Inductee,    1988

Children’s Brain Tumor Foundation, Project Program Grant,    2000

Emily Dorfman Foundation for Children,    2001-2003

Save a Child’s Heart Foundation,    2003

Resident Teaching Award, Department of Neurological Surgery (NYPH-WMC),    2004, 2005

Isabel Gloria Neidorf Research Grant,    2004-2007

Castle Connolly Top Doctors (New York Metro Area),    2004-2018

Beez Foundation Research Grant,    2005-2006

Lehman Brothers Foundation Award,    2006-2009

Children’s Hope Award,    2007

Pediatric Brain Tumor Foundation Research Grant,    2007-2008

Clinical & Translational Science Center Pilot Award,    2008

Nina W. Werblow Charitable Trust Award,    2009

Consumers’ Research Council of America Top Surgeons Award,    2010

Beez Foundation Research Grant,    2010

The Cure Starts Now Foundation Research Grant,    2010

The Cristian Rivera Foundation Award,    2010

Dana Neuroimmnology Foundation,    2010

St. Baldrick’s Foundation,    2010

Employee of the Year for Department of Neurological Surgery (NYPH-WMC),    2010, 2011

Cristian Rivera Vision of Hope Award,    2012, 2013, 2014

New York Magazine’s Best Doctors,    2012-2014

Louis and Rachel Rudin Foundation, Inc.,    2012-2014

Castle Connolly Best Doctors (nationwide),    2010-2015

McKenna Claire Foundation Research Grant,    2014

Cristian Rivera Vision of Hope Award,    2014

Chiari & Syringomyelia Foundation Award,    2015

New York Magazine’s Best Doctors,    2016 

Breakthrough Spirit Award, Children’s Cancer & Blood Foundation,    2016

Cristian Rivera Foundation Vison of Hope Award,    2016

Brain Tumor Foundation Award,    2016

TSC NYC Marathon Finisher: 5:05:44,    2018

Oncology Times, Excellence in Oncology Award Contest Honorable Mention, 2019

5th Anniversary, 2014-2019 Castle Connolly Top Doctors, 2019

New York Magazine's Best Doctors in New York, 2019

Rofeh Cholim Cancer Society Medical Devotion Award, 2019

Special Licenses/Certifications:

American Board of Pediatric Neurological Surgery    Nov. 2021

Professional Activity:

Alpha Omega Alpha Honorary Society, Member    1988-present

American Medical Association, Member,    1988-present

American Association of Neurological Surgeons, Member,    1989-present

Congress of Neurological Surgeons, Member,    1989-present

Joint Section on Pediatric Neurological Surgery, Member,    1993-present

Children’s Oncology Group, Member,    1995-present

New York State Neurosurgical Society, Member,    1995-present

Medical Society of the State of New York, Member,    1995-present

Hydrocephalus Association, Member,    1996-present

Young Neurosurgeons Committee, Member,    1997-1999

Society of Neuro-Oncology, Member,    2000-present

Joint Section on Tumors (AANS/CNS), Member,    2001-present

American Society of Pediatric Neurosurgeons, Member,    2001-present

American College of Surgeons, Fellow,    2001-present

Society of University Neurosurgeons, Member,    2002- present

American Academy of Pediatrics, Fellow,    2002- present

International Society of Pediatric Neurosurgery, Member,    2003-present

The World Association of Lebanese Neurosurgeons, Member,    2004-present

The Society of Neurological Surgeons, Member,    2004-present

The New York Clinical Society, Member,    2004-present

The New York Society of Neurosurgery, Member,    2005-present

CNS Steering Committee, Children’s Oncology Group, Member,    2016-present

The New York Academy of Sciences,    2018-present

International Organizing Committee, International Symposium on Pediatric Neuro-Oncology (ISPNO),    2019

Publications, Lectures and Presentations:

1. Articles in professional peer-reviewed journals

1. Bander E, Tizi K, Wenbacher-Schroeder E, Thomson R, Donzelli M, Vasconcellos E, Souweidane MM. Deformational Changes after Convection-Enhanced Delivery in the Pediatric Brain Stem. Journal of Neurosurgery. October 2019 [Accepted for publication].
2. Guo H, Kommidi H, Maachani UB, Voronina JC, Zhang W, Magge RS, Ivanidze J, Wu AP, Souweidane MM, Aras O, Ting R. An [18F]-Positron Emitting Fluorophore Allows Safe Evaluation of Small Molecule Distribution in the CSF, CSF Fistulas, and CNS Device Placement. Mol Pharm. 2019 Jul 10. Doi: 10.1021/acs.molpharmaceut.9b00485. [Epub ahead of print].
3. Farouk Sait S, Haque S, Karimi S, Rebeiz KJ, Francis JH, Marr BP, Abramson DH, Souweidane MM, Dunkel IJ. A Potential Role for Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma. J. Pediatr Hematol Oncol. 2019. Jun 27 [Epub ahead of print].
4. Chang Raymond, Tosi Umberto, Voronina Julia, Oluwaseyi Adeuyan, Y Linda Wu, Melanie E. Schweitzer, David J Pisapia, Oren J. Brecher, Mark M Souweidane, Uday B Maachani. Combine Targeting of P13K and MEK Effector Pathways via CED for DIPG Therapy. Neuro-Oncology Advances May 2019 [accepted for publication]
5. Kuzan-Fischer CM, Souweidane MM. The oscillating intersect of neurosurgery with diffuse intrinsic pontine glioma. JNSPG 75th Anniversary invited review article. May 2019. [accepted for publication].
6. Cheng D, Yuan M, Perera I, O’Connor, Evins A, Imahiyerobo T, Souweidane M, Hoffman C. Development of a Novel 3D Printed Model of Surgical Simulation Training in Cranial Vault Remodelling. Journal of Neurosurgery: Pediatrics. 2019 [accepted for publication].
7. Miller AM, Shah RH, Pentsova EL, Pourmaleki M, Briggs S, Distefano N, Zheng Y, Skakodub A, Mehta SA, Campos C, Hsieh WY, Selcuklu SD, Ling L, Meng F, Jing X, Samoila A, Bale TA, Tsui DWY, Grommes C, Viale A, Souweidane MM, Tabar V, Brennan CW, Reiner AS, Rosenblum M, Panageas KS, DeAngelis LM, Young RJ, Berger MF, Mellinghoff IK. Tracking Tumour Evolution in Glioma Through Liquid Biopsies of Cerebrospinal Fluid. Nature. 2019 Jan;565(7741):654-658. doi: 10.1038/s41586-019-0882-3.
8. Jacques J. Lara-Reyna, Rafael Uribe Cardenas, Imali Perera, Nicholas Szerlip, Anastasios Giamouriadis, Nicole Savage, Therese Haussner, Mark M Souweidane. Endoscopic Removal of Recurrent Colloid Cysts. J Neurosurg 2019 Apr 12:1-6. Doi: 10.3171/2018.12JNS181859 [eupb ahead of print].
9. Hoffman CE, Yuan M, Boyke A, O’Connor A, Haussner T, Perera I, Souweidane MM. Impact of Advanced Practice Provider Directed Plagiocephaly Clinic for Neurosurgical Practices. J Neurosurg Pediatr. 2019 Mar 29:1-4. Doi: 10.3171/2019.
10. Tosi U, Kommidi H, Bellat V, Marnell CS, Guo H, Adeuyan O, Schweitzer ME, Chen N, Su T, Zhang G, Maachani UB, Pisapia DJ, Law B, Souweidane MM, Ting R. Real-Time, in Vivo correlation of Molecular Structure with drug Distribution in the Brain Striatum Following Convection Enhanced Delivery. ACS Chem Neurosci 2019 May 15;10(5):2287-2298. Doi: 10.1021/aschermneuro.8b00607.
11. Lopez M, Morrison K, Lee J, Hoffman CE, Souweidane MM, Ascherman JA. Calculated Blood Loss and Transfusion Requirements in Primary Open Repair of Craniosynostosis. Plast Reconstr Surg Glob Open 2019 Feb 8;7(2):e2112. Doi: 10.1097/GOX.0000000000002112.
12. Fangusaro J, Shengjie W, MacDonald S, Murphy E, Shaw D, Bartels U, Soumen K, Souweidane MM, Lu H, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G. Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Non-Germinomatous Germ Cell Tumors: A Children’s Oncology Group Study. Journal of Clinical Oncology 2019 [Accepted for publication].
13. Morgenstern PF, Zhou Z, Wenbacher-Schroder E, Cina V, Tsiouris AJ, Souweidane MM. Clinical tolerance of corticospinal tracts in convection-enhanced delivery to the brainstem. J Neurosurg 2018 Dec. 21:1-7. Doi: 10.3171/2018.6.JNS18854. [Epub ahead of print].
14. Ordonez-Rubiano EG, Forbes JA, Morgenstern PF, Arko L, Dobri GA, Greenfield JP, Souweidane MM, Tsiouris AJ, Anand Vk, Kacker A, Schwartz TH. Preserve or sacrifice the stalk? Endocrinological outcomes, extent of resection, and recurrence rates following endoscopic endonasal resection of craniopharyngiomas. J Neurosurg 2018 Nov 1:1-9. Doi: 10.3171/2018.6JNS18901 [Epub ahead of print].
15. Souweidane MM, Kramer K, Pandit-Taskar N, Zhou Z, Haque S, Zanzonico P, Carrasquillo J, Lyashchenko S, Thakur S, Donzelli M, Turner R, Lewis J, Cheung N, Larson S, Dunkel I. Convection-enhanced delivery for diffuse intrinsic pontine glioma: a single-centre, dose-escalation, phase 1 trial. Lancet Oncol 2018 Aug;19(8):1040-1050. doi: 10.1016/S1470-2045(18)30322..
16. Jannetti SA, Carlucci G, Carney B, Kossatz S, Shenker L, Carter LM, Salinas B, Brand C, Sadique A, Donabedian PL, Cunanan KM, Gonen M, Ponomarev V, Zeglis BM, Souweidane MM, Lewis JS, Weber WA, Humm JL, Reiner T. PARP1-Targeted Radiotherapy in Mouse Models of Glioblastoma. J Nucl Med. 2018 Aug;59(8):1225-1233. doi: 10.2967/jnumed.117.205054.
17. Singh H, Burhan Janjua M, Ahmed M, Esquenazi Y, Dhandapani S, Mauer E, Schwartz TH, Souweidane M. Factors influencing outcome in patients with colloid cysts who present with acute neurological deterioration. J Clin Neurosci. 2018 Aug;54:88-95. Doi: 10.1016/j.ocn.2018.06.006.
18. Morrison KA, Lee JC, Souweidane MM, Feldstein NA, Ascherman JA. Twenty-Year Outcome Experience with Open Craniosynostosis Repairs: An Analysis of Reoperation and Complication Rates. Ann Plast Surg. 2018 Apr;80(4 Suppl 4): S158-S163 doi: 10.1097/SAP.0000000000001365.
19. Singh R, Bellat V, Want M, Schweitzer ME, Wu YL, Tung CH, Souweidane MM, Law B. Volume of distribution and clearance of peptide-based nanofiber after convection-enhanced deliver. J Neurosurg. 2017 Sep 8:1-9. Doi: 10.3171/2017.2.JNS162273.
20. De B, Khakoo Y, Souweidane MM, Dunkel IJ, Patel SH, Gilheeney SW, De Braganca KC, Karajannis MA, Wolden SL. Patterns of relapse for children with localized intracranial ependymoma. J Neurooncol. 2018 Jun;138(2):435-445. doi: 10.1007/s11060-018-2815-7.
21. Kommidi H, Tosi U, Maachani UB, Guo H, Marnell CS, Law B, Souweidane MM, Ting R. 18F-Radiolabeled Panobinostat Allows for Positron Emission Tomography Guided Delivery of a Histone Deacetylase Inhibitor. ACS med Chem Lett. 2018 Jan 17;9(2):114-119. doi: 10.1021/acsmedchemlett.7b00471.
22. Alalade AF, Ogando-Rivas E, Boatey J, Souweidane MM, Anand VK, Greenfield JP, Schwartz TH. Suprasellar and recurrent pediatric craniopharyngiomas: expanding indications for the extended endoscopic transphenoidal approach. J Neurosurg Pediatr. 2018 Jan;21(1):72-80. doi: 10.3171/2017.7.PEDS17295.
23. De B, Beal K, De Braganca KC, Souweidane MM, Dunkel IJ, Khakoo Y, Gilheeney SW, DeAngelis LM, Menzel P, Patel SH, Wolden SL. Long-term outcomes of adult medulloblastoma patients treated with radiotherapy. J Neurooncol. 2018 Jan;136(1):95-104. doi: 10.1007/s11060-017-2627-1.
24. Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV. A Phase II study of radiommunotherapy with intraventricular (131) I-3F8 for medulloblastoma. Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26754.
25. Omay SB, Chen YN, Almeida JP, Ruiz-Trevino AS, Boockvar JA, Stieg PE, Greenfield JP, Souweidane MM, Kacker A, Pisapia DJ, Anand VK, Schwartz TH. Do Crainopharyngioma molecular signatures correlate with clinical characteristics? J Neurosurg. 2018 May, 128(5):1473-1478 doi: 10.3171/2017.1.JNS162232.
26. Wu YL, Maachani UB, Schweitzer M, Singh R, Wang M, Chang R, Souweidane MM. Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells. Transl Oncol. 2017 Apr;10(2):221-228. doi: 10.1016/j.tranon.2016.12.008.
27. Kossatz, S, Carney B, Schweitzer m, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15;77(8):2112-2123. doi: 10.1158/00008-5472.CAN-16-2850.
28. Tosi U, Marnell CS, Chang R, Cho WC, Ting R, Maachani UB, Souweidane MM. Advances in Molecular Imaging of Locally Delivered Targeted Therapeutics for Central Nervous System Tumors. Int J Mol Sci. 2017 Feb 8;18(2). Pii: E351. doi: 10.3390/ijms18020351.
29. Zhou Z, Luther N, Singh R, Boockvar JA, Souweidane MM, Greenfield JP. Glioblastoma spheroids produce infiltrative gliomas in the rat brainstem. Childs Nerv Syst. 2017 Mar;33(3):437-446. doi: 10.1007/s00381-017-3344-y.
30. Zhou Z, Singh R, Souweidane MM. Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment. Curr Neruopharmacol. 2017;15(1):116-128.
31. Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.16.00038.
32. Wang M, Kommidi H, Tosi U, Guo H, Zhou Z, Schweitzer ME, Wu LY, Singh R, Hou S, Law B, Ting R, Souweidane MM. A Murine model for Quantitative, Real-Time Evaluation of Convection-Enhanced Delivery (RT-CED) Using an (18)[F]-Positron Emitting, Fluorescent Derivative of Dasatinib. Mol Cancer Ther. 2017 Dec;16(12):2902-2912. Doi: 10.1158/1535-7163.MCT-17-0423.
33. Donson AM, Apps J, Griesinger AM, Amani V, Witt Da, Anderson RCE, Niazi TN, Grant G, Souweidane M, Johnston JM, Jackson EM, Kleinschmidt-DeMasters BK, Handler MH, Tan AC, Gore L, Virasami A, Gonzalez-Meljem JM, Jacques TS, Martinez-Barbera JP, Foreman NK, Hankinson TC. Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Crainopharyngioma. J Neuropthol Exp Neurol. 2017 Sep 1;76(9):779-788. Doi: 10.1093/jnen/n1x061.
34. Janjua MB, Hoffman CE, Souweidane MM, Contemporary management and surveillance strategy after shunt or endoscopic third ventriculostomy procedures for hydrocephalus. J Clin Neurosci. 2017 Nov;45:18-23. doi: 10.1016/jocn.2017.07.004.
35. Janjua MB, Ivasyk I, Pisapia DJ, Souweidane MM. Ganglioglioma of brain stem and cervicomedullary junction: A 50years review of literature. J Clin Neurosci. 2017 Oct;44:34-46. doi: 10.1016/j.jcon.2017.06.021.
36. Ivasyk I, Morgenstern PF, Wembacher-Schroeder E, Souweidane MM. Influence of an intratumoral cyst on drug distribution by convection-enhanced delivery: case report. J Neurosurg Pediatr. 2017 Sep;20(3):256-260. doi: 10.3171/2017.5.PEDS1774.
37. De B, Cahlon O, Dunkel IJ, De Braganca KC, Khakoo Y, Gilheeney SW, Souweidane MM, Wolden SL. Reduced-volume radiotherapy for patients with localized intracranial nongerminoma germ cell tumors. J Neurooncol. 2017 Spe;134(2):349-356. doi: 10.1007/s11060-017-2532-7.
38. Janjua MB, Caruso JP, Greenfield JP, Souweidane MM, Schwartz TH. The combined transpetrosal approach: Anatomic study and literature review. J Clin Neurosci. 2017 Jul;41:36-40. doi: 10.1016/j.jcon.2017.03.015.
39. Dhandapani S, Singh H, Negm HM, Cohen S, Souweidane MM, Greenfield JP, Anand VK, Schwartz TH. Endonasal endoscopic reoperation for residual or recurrent craniopharyngiomas. J Neurosurg. 2017 Feb;126(2):418-430. doi: 10.3171/2016.1.JNS152238.
40. Singh R, Zhou Z, Tisnado J, Haque S, Peck KK, Young RJ, Tsiouris AJ, Thakur SB, Souweidane MM. A novel magnetic resonance imaging segmentation technique for determining diffuse intrinsic pontine glioma tumor volume. J Neurosurg Pediatr. 2016 Nov;18(5):565-572.
41. Guisado DI, Singh R, Minkowitz S, Zhou Z, Haque S, Peck KK, Young RJ, Tsiouris AJ, Souweidane MM, Thakur SB. A Novel methodology for applying Multivoxel MR Spectroscopy to evaluate Convection-Enhanced Drug Delivery in Diffuse Intrinsic Pontine Gliomas. AJNR Am J Neuroradiol. 2016 Jul;37(7):1367-73. doi: 10.3174/ajnr.A4713.
42. Abdel Latif AM, Souweidane MM. Extruded contents of colloid cysts after endoscopic removal. J Neurosurg. 2016 Sep;125(3):570-5. doi: 10.3171/2015.6JNS142676.
43. Morgenstern PF, Hoffman Ce, Kocharian G, Singh R, Stieg PE, Souweidane MM. Postoperative imaging for detection of recurrent arteriovenous malformations in children. J Neurosurg Pediatr. 2016 Feb;17(2):134-140.
44. Margetis K, Rajappa P, Cope W, Pisapia D, Souweidane MM. Endoscopic diagnosis of an MRI-occult, low-grade glioma with ependymal dissemination. J Neurosurg Pediatr. 2015 Oct;16(4):377-82. Doi: 10.3171/2015.3.PEDS14444.
45. Kramer K, Pandit-Taskar N, Zanzonico P, Wolden SL, Humm JL, DeSelm C, Souweidane MM, Lewis JS, Cheung NK. Low incidence of radionecrosis in children treated with conventional radiation therapy and intrathecal radiommunotherapy. J Neurooncol. 2015 Jun;123(2):245-9. Doi: 10.1007/s11060-015-1788-z.
46. Xu R, McCrea HJ, Hoffman CE, Souweidane MM, Greenfield JP. The Impact of Endoscopic Third Ventriculostomy on Shunt Revision Rate: A 14-Year Experience at a Single Institution. World Neurosurg. 2015 Sep;84(3):677-680.el. doi: 10.1016/j.wneu.2015.04.037.
47. Patel KS, Raza SM, McCoul ED, Patrona A, Greenfield JP, Souweidane MM, Anand VK, Schwartz TH. Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas. J Neurosurg. 2015 Sep;123(3):571-80. doi: 10.3171/2014.12.JNS141591.
48. Zerah m, Piguet F, Colle MA, Raoul S, Deshcamps JY, Deniaud J, Gautier B, Toulgoat F, Bieche I, Laurendeau I, Sondhi D, Souweidane MM, Cartier-Lacave N, Moullier P, Crystal RG, Roujeau T, Sevin C, Aubourg P. Intracerebral Gene Therapy Using AAVrh.10-hARSA Recombinant Vector to Treat Patients with Early-Onset Forms of Metachromatic Leukodystrophy: Preclinical Feasibility and Safety Assessments in Nonhuman Primates. Hum Gene Ther Clin Dev. 2015 Jun;26(2):113-24. doi: 10.1089/humc.2014.139.
49. Zhou Z, Ho SL, Singh R, Pisapia DJ, Souweidane MM. Toxicity evaluation of convection-enhanced delivery of small molecule kinase inhibitors in naïve mouse brainstem. Childs Nerv Syst. 2015 Apr;31(4):557-62. doi: 10.1007/s00381-015-2640-7.
50. Souweidane MM. Laser ablation for recurrent intracranial ependymoma. J Neurosurg Pediatr. 2015 Apr;15(4):361-2. doi: 10.3171/2014.8.PEDS14297.
51. Souweidane MM. Periodical shifts in surgical correction of sagittlal craniosynostosis. J Neurosurg Pediatr. 2015 Apr;15(4):347-8. doi: 10.3171/2014.9.PEDS14350.
52. Giannetti AV, Alvarenga AY, de Lima To, Pedrosa HA, Souweidane MM. Neuroendoscopic biopsy of brain lesions: accuracy and complications. J Neurosurg. 2015 Jan;122(1):34-9. Doi: 10.3171/2014.9.JNS132648.
53. Ho SL, Singh R, Zhou Z, Lavi E, Souweidane MM. Toxicity evaluation of prolonged convection-enhanced delivery of small-molecule kinase inhibitors in naïve rat brainstem. Childs Nerv Syst. 2015 Feb;31(2):221-6. Doi: 10.1007/s00381-014-2568-3
54. Souweidane MS. Combined choroid plexus coagulation and endoscopic third ventriculostomy: is North America ready? J Neurosurg Pediatr. 20143 Spe;14(3):221-3. doi: 10.3171/2014.4.PEDS1450.
55. Banu MA, Rathman A, Patel KS, Souweidane MM, Anand VK, Greenfield JP, Schwartz TH. Corridor-based endonasal endoscopic surgery for pediatric skull base pathology with detailed radioanatomic measurements. Neurosurgery. 2014 Jun;10 Suppl 2:273-93; discussion 293. doi: 10.1227/NEU.000000000000000252.
56. Kramer K, Smith M, Souweidane MM. Safety profile of long-term intraventricular access devices in Pediatric patients receiving radiommunotherapy for central nervous system malignancies. Pediatr Blood Cancer. 2014 Sep;61(9):1590-2. Doi: 10.1002/pbc.25080.
57. Margetis K, Christos PJ, Souweidane M. Endoscopic resection of incidental colloid cysts. J Neurosurg. 2014 June;120(6):1259-67. Doi: 10.3171/2014.3.JNS131289.
58. Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U, Zuccaro J, Agnihotri S, Ryall S, Barszczyk M, Chornenkyy Y, Bourgey M, Bourque G, Montpetit A, Cordero F, Castelo-Branco P, Mangerel J, Tabori U, Ho KC, Huang A, Taylor KR, Mackay A, Bendel AE, Nazarian J, Fangusaro JR, Karajannis MA, Zagzag D, Foreman NK, Donson A, Hegert JV, Smith A, Chan J, Lafay-Cousin L, Dunn S, Hukin J, Dunham C, Scheinemann K, Michaud J, Zelcer S, Ramsay D, Cain J, Brennan C, Souweidane MM, Jones C, Allis CD, Brudno M, Becher O, Hawkins C. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet. 2014 May;45(5):451-6. doi: 10.1038/ng.2936.
59. Luther N, Zhou Z, Zanzonico P,
Cheung NK, Humm J, Edgar MA, Souweidane MM. The potential of therognostic 124I-8H9 convection-enhanced delivery in diffuse intrinsic pontine glioma. Neuro Oncol. 2014 Jun;16(6):800-6. doi: 10.1093/neuonc/not298.
60. Hoffman CE, Santillan A, Rotman L, Gobin YP, Souweidane MM. Complications of cerebral angiography in children younger than 3 years of age. J Neurosurg Pediatr. 2014 Apr;13(4):414-9. doi: 10.3171/2013.12.PEDS13172.
61. Souweidane MM. Editorial: Convection-enhanced delivery for diffuse intrinsic pontine glioma. J Neurosurg Pediatr. 2014 Mar;13(3):273-4. doi: 10.3171/2013.10.PEDS13421.
62. Martinez S, Khakoo Y, Gilheeney S, Kramer K, Wolden S, Souweidane M, Dunkel IJ. Marker (+) CNS germ cell tumors in remission: are surveillance MRI scans necessary? Pediatr Blood Cancer. 2014 May;61(5):853-4. doi: 10.1002/pbc.24888.
63. Banu MA, Guerrero-Maldonado A, McCrea HJ, Garcia-Navarro V, Souweidane MM, Anand VK, Heirer L, Schwartz TH, Greenfield JP. Impact of skull base development on endonasal endoscopic surgical corridors. J Neurosurg Pediatr. 2014 Feb;13(2):155-69. doi: 10.3171/2013.10.PEDS13303.
64. Fischer C, Haque SS, Huse JT, Blochin E, Souweidane MM, Lis E, Khakoo Y.
Extraneural ependymoma: distant bone, lung, liver, and lymph node metastases following bevacizumab. Pediatr Blood Cancer. 2013 Jan;60(1):143-5. doi: 10.1002/pbc.24268.
65. Margetis K, Souweidane MM. Endoscopic resection of colloid cyst in normal-sized ventricular system. Neurosurg Focus. 2013 Jan;34(1 Suppl): video 8. doi: 10.3171/2013.V1.FOCUS12329.
66. Zhou Z, Luther N, Ibrahim GM, Hawkins C, Vibhakar R, Handler MH, Souweidane MM. B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma. J Neurooncol. 2013 Feb;111(3):257-64. Doi: 10.1007/s11060-012-1021-2.
67. Morgenstern PF, Souweidane MM. Pineal region tumors: simultaneous endoscopic third ventriculostomy and tumor biopsy. World Neurosurg. 2013 F3b;79(2 Suppl):S18.e9-13. doi: 10.1016/j.wneu.2012.02.020.
68. Margetis K, Souweidane MM. Endoscopic treatment of intraventricular cystic tumors. World Neurosurg. 2013 Feb;79(2 Suppl):s19.e1-11. doi: 10.1016/jwneu.2012.02.021.
69. Dyke JP, Sondhi D, Voss HU, Shungu DC, Mao X, Yohay K, Worgall S, Hackett NR, Hollmann C, Yeotsas ME, Jeong AL, Van de Graaf B, Cao I, Kaminsky SM, Heier LA, Rudser KD, Souweidane MM, Kaplitt MG, Kosofsky B, Crystal RG, Ballon D. Assessment of disease severity in late infantile neuronal ceroid lipofuscinosis using multiparametric MR imaging. AJNR Am J Neuroradiol. 2013 Apr;34(4):884-9. doi: 10.3174/ajnr.A3297.
70. Orlin A, Sondhi D, Witmer MT, Wessel MM, Mezey JG, Kaminsky SM, Hackett NR Yohay K, Kosofsky B, Souweidane MM, Kaplitt MG, D’Amico DJ, Crystal RG, Kiss S. Spectrum of ocular manifestations in CLN2-associated batten (Jansky-Bielschowsky) disease correlate with advancing age and deteriorating neurological function. PLoS One. 2013 Aug 28;8(8):e73128. doi: 10.1371/journal.pone.0073128.
71. Hoffman CE, Savage NJ, Souweidane MM. The significance of cyst remnants after endoscopic colloid cyst resection: a retrospective clinical case series. Neurosurgery. 2013 Aug;73(2):233-7; discussion 237-9. doi: 10.1227/01.neu.0000430300.10338.71.
72. Sondhi D, Johnson L, Purpura K, Monette S, Souweidane MM, Kaplitt MG, Kosofsky B, Yohay K, Ballon D, Dyke J, Kaminsky SM, Hackett NR, Crystal RG. Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Hum Gene Ther Methods. 2012 Oct;23(5):324-35. doi: 10.1089/hgtb.2012.120.
73. Litkowski P, Young RJ, Wolden SL, Souweidane MM, Haque S, Gilheeney SW. Collision in the inferior olive: hypertrophic olivary degeneration complicated by radiation necrosis in brainstem primitive neuroendocrine tumor. Clin Imaging. 2012 July-Aug;36(4):371-374. doi: 10.1016/j.clinimag.2011.09.014.
74. McCrea HJ, Knopman J, Engel M, Rina HA, Souweidane MM, Schwartz TH, Greenfield JP. Concurrent anatomic Hemispherectomy and thalamic arteriovenous malformation resection. Childs Nerv Syst. 2012 Aug;28(8):1273-7. doi: 10.1007/s00381-012-1812-y.
75. Kirksey MA, Issack PS, Edmonds CR, Souweidane MM, Lee A, Perlman S, Zayas V, Boachie-Adjei O. Fatal cerebral swelling Associated with Scoliosis Surgery in two Patients with Neuromuscular Scoliosis and congenital Hydrocephalus: a Report of Two Cases. JBJS Case Connect. 2012 Apr-June;2(2):e23. doi: 10.2106/JBJS.CC.K.00087.
76. Leng LZ, Greenfield JP, Souweidane MM, Anand VK, Schwartz TH. Endoscopic, endonasal resection of craniopharyngiomas: analysis of outcome including extent of resection, cerebrospinal fluid leak, return to preoperative productivity, and body mass index. Neurosurgery. 2012 Jan;70(1):110-23; discussion 123-4. doi: 10.1227/NEU.0b013e31822e8ffc.
77. Litkowski P, Khakoo Gilheeney S, Souweidane M, Huse J, Haque S, Young RJ. Hemangioma of the cavernous sinus in a child. Neurology. 2011 Oct 25;77(17):1647-8. doi: 10.1212/WNL.0b013e3182343399.
78. Qiao L, Souweidane MM. Purely endoscopic removal of intraventricular brain tumors: a consensus opinion and update. Minim Invasive Neurosurg. 2011 Aug;54(4):149-54. Doi: 10.1055/s-0031-1284386.
79. Bartels U, Hawkins C, Vezina G, Kun L, Souweidane M, Bouffet E. Proceedings of the diffuse intrinsic pontine glioma (DIOG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG. J Neurooncol. 2011 Oct;105(1):119-25. Doi: 10.1007/s11060-011-0704-4.
80. Bakst RL, Dunkel IJ, Gilheeney S, Khakoo Y, Becher O, Souweidane MM, Wolden SL. Reirradiation for recurrent medulloblastoma. Cancer. 2011 Nov 1;117(21):4977-82. doi: 10.1002/cncr.26148.
81. Polkinghorn WR, Dunkel IJ, Souweidane MM, Khakoo Y, Lyden DEC, Gilheeney SW, Becher OJ, Budnick AS, Wolden SL. Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma. Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):e15-20. doi: 10.1016/j.ijrobp.2010.11.081.
82. Morgenstern PF, Osbun N, Schwartz TH, Greenfield JP, Tsiouris AJ, Souweidane MM. Pineal region tumors: an optimal approach for simultaneous endoscopic third ventriculostomy and biopsy. Neurosurg Focus. 2011 Apr;30(4):E3. doi: 10.3171/2011.2.FOCUS10301.
83. Hoffman C, Riina HA, Stieg P, Allen B, Gobin YP, Santillan A, Souweidane M. Associated aneurysms in pediatric arteriovenous malformations and the implications for treatment. Neurosurgery. 2011 Aug;69(2):315-22. doi: 10.1227/NEU.0b013e31821524al.
84. Gursel DB, Beyene RT, Hofstetter C, Greenfield JP, Souweidane MM, Kaplitt M, Arango-Lievano M, Howard B, Boockvar JA. Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction. J Neurooncol. 2011 Sep;104(2):509-22. doi: 10.1007/s11060-011-0528-2.
85. Shyu C, Burke K, Souweidane MM, Dunkel IJ, Gilheeney SW, Gershon T, Khakoo Y. Novel use of zolpidem in cerebellar mutism syndrome. J Pediatr Hematol Oncol. 2011 Mar;33(2):148-9. doi: 10.1097/MPH.0b013e3182053a1a.
86. Chater-Cure G, Hoffman C, Knopman J, Rhee S, Souweidane MM. Endoscopy-assisted removal of periorbital inclusion cysts in children. J Neurosurg Pediatr. 2011 Feb;7(2):161-4. doi: 10.3171/2010.11.PEDS10332. (Selected as cover illustration)
87. Souweidane MM. Chiari malformation Type I. J Neurosurg Spine. 2010 Dec;13(6):727-8; discussion 728. doi: 10.3171/2010.5.SPINE10213.
88. Souweidane MM. Anterior third ventriculostomy: an endoscopic variation on a theme. J Neurosurg. 2010 Dec;113(6):1259-60; discussion 1260. doi: 10.3171/2009.11.JNS091698.
89. Souweidane MM, Krieger MD, Weiner HL, Finlay JL. Surgical management of primary central nervous system germ cell tumors: proceedings from the Second international Symposium on Central Nervous System Germ Cell Tumors. J Neurosurg Pediatr. 2010 Aug;6(2):125-30. doi: 10.3171/2010.5.PEDS09112.
90. Souweidane MM, Fraser JF, Arkin LM, Sondhi D, Hackett NR, Kaminsky SM, Heier L, Kosofsky BE, Worgall S, Crystal RG, Kaplitt MG. Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. J Neurosurg Pediatr. 2010 Aug;6(2):115-22. doi: 10.3171/2010.4.PEDS09507. (Selected as cover illustration)
91. Rubin D, Santillan A, Greenfield JP, Souweidane M, Riina HA. Surgical management of pediatric cerebral arteriovenous malformations. Childs Nerv Syst. 2010 Oct;26(10):1337-44. doi: 10.1007/s00381-010-1211-1.
92. Riina Ha, Knopman J, Greenfield JP, Fralin S, Gobin YP, Tsiouris AJ, Souweidane MM, Boockvar JA. Balloon-assisted superselective intra-arterial cerebral infusion of bevacizumab for malignant brainstem glioma. A technical note. Interv Neuroradiol. 2010 Mar;16(1):71-6.
93. Luther N, Cheung NK, Souliopoulos EP, Karampelas I, Bassiri D, Edgar MA, Guo HF, Pastan I, Gutin PH, Souweidane MM. Interstitial infusion of glioma-targeted recombinant immunotoxin 8H9scFv-PE38. Mol Cancer Ther. 20140 Apr;9(4):1039-46. doi: 10.1158/1535-7163.MCT-09-0996.
94. Souweidane MM. Posterior fossa syndrome. J Neurosurg Pediatr. 2010 Apr;5(4):325-6; discussion 326-8. doi: 10.3171/2009.11.PEDS09369.
95. Croog VJ, Kramer K, Cheung NK, Kushner BH, Modak S, Souweidane MM, Wolden SL. Whole neuraxis irradiation to address central nervous system relapse in high-risk neuroblastoma. Intl J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):849-54. doi: 10.1016/j.ijrobp.2009.09.005.
96. Souweidane MM, Morgenstern PF, Kang S, Tsiouris AJ, Roth J. Endoscopic third ventriculostomy in patients with a diminished prepontine interval. J Neurosurg Pediatr. 2010 Mar;5(3):250-4. doi: 10.3171/2009.10.PEDS.09187. (Selected as cover illustration)
97. Luther N, Stetler WR Jr, Dunkel IJ, Christos PJ, Wellons JC 3rd, Souweidane MM. Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy. J Neurosurg Pediatr. 2010 Jan;5(1)61-7. doi: 10.3171/2009.7.PEDS0971
98. Gilheeney SW, Khakoo Y, Souweidane M, Wolden S, Boulad F, Dunkel IJ. Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis, pediatric malignancies of the central nervous system. Gilheeney SW, Khakoo Y, Souweidane M, Wolden S, Boulad F, Dunkel IJ. Pediatr Blood Cancer. 2010 Apr;54(4):591-5. doi: 10.1002/pbc.22347.
99. Dunkel IJ, Jubran RF, Gururangan S, Chantada GL, Finlay JL, Goldman S, Khakoo Y, O’Brien JM, Orjuela M, Rodriguez-Galindo C, Souweidane MM, Abramson DH. Trilateral retinoblastoma: potentially curable with intensive chemotherapy. Pediatr Blood Cancer. 2010 Mar;54(3):384-7. doi: 10.1002/pbc.22336.
100. Kramer K, Kushner BH, Modak S, Pandit-Tasker N, Smith-jones P, Zanzonico P, Humm JL, Xu H, Wolden SL, Souweidane MM, Larson SM, Cheung NK. Compartmental intrathecal radiommunotherapy: results for treatment for metastatic CNS neuroblastoma. J Neurooncol. 2010 May;97(3):409-18. doi: 10.1007/s11060-009-0038-7.
101. Souweidane MM. Intraoperative magnetic resonance imaging. J Neurosurg Pediatr. 2009 Nov;4(5):465-6; discussion 466. doi: 10.3171/2009.5.PEDS09199.
102. Souweidane MM. The evolving role of surgery in the management of pediatric brain tumors. J Child Neurol. 2009 Nov;24(11):1366-747. doi: 10.1177/08830738093242274.
103. Souweidane MM, Morgenstern PF, Christos PJ, Edgar MA, Khakoo Y, Rutka JT, Dunkel IJ. Intraoperative arachnoid and cerebrospinal fluid sampling in children with posterior fossa brain tumors. Neurosurgery. 2009 Jul;65(1):72-8. doi: 10.1227/01.NEU.0000348011.98625.43
104. Dunkel IJ, Souweidane MM. Pontine glioma. J Neurosurg Pediatr. 2009Apr;3(4):257; author reply 257-8. doi: 10.3171/2008.12.PEDS08388.
105. Becher OJ, Souweidane M, Lavi E, Kramer K, Lis E, Marghoob AA, Khakoo Y. Large congenital melanotic nevi in an extremity with neurocutaneous melanocytosis. Pediatr Dermatol. 2009 Jan-Feb;26(1):79-82. doi: 10.1111/j.1525-1470.2008.00828.x.
106. Luther N, Karampelas I, Souliopoulos EP, Edgar MA, Boockvar JA, Souweidane MM. Interstitial infusion of erlotinib in the rodent brain. J Exp Ther Oncol. 2009;8(2):79-84.
107. Luther N, Cheung NK, Dunkel IJ, Fraser JF, Edgar MA, Gutin PH, Souweidane MM. Intraparenchymal and intratumoral interstitial infusion of anti-glioma monoclonal antibody 8H9. Neurosurgery. 2008 Dec;63(6):1166-74; discussion 1174. doi: 10.1227/01.NEU.0000334052.60634.84.
108. Knopman J, Tsiouris AJ, Souweidane MM. Atraumatic epidural hematoma secondary to a venous sinus thrombosis: a novel finding. J Neurosurg Pediatr. 2008 Dec;2(6):416-9. doi: 10.317/PED.2008.2.12.416.
109. Greenfield JP, Hoffman c, Kuo E, Christos PJ, Souweidane MM. Intraoperative assessment of endoscopic third ventriculostomy success. J Neurosurg Pediatr. 2008 Nov;2(5):298-303. doi: 10.3171/PED.2008.2.11.298.
110. Greenfield JP, Leng LZ, Chaudhry U, Brown S, Anand VK, Souweidane MM, Schwartz TH. Combined simultaneous endoscopic transphenoidal and endoscopic transventricular resection of a giant pituitary macroadenoma. Mimim Invasive Neurosurg. 2008 Oct;51(5):306-9. doi: 10.1055/s-0028-1082323.
111. Souweidane MM, Hoffman CE, Schwartz TH. Transcavum interforniceal endoscopic surgery of the third ventricle. J Neurosurg Pediatr. 2008 Oct;2(4):231-6. doi: 10.3171/PED.2008.2.10.231. (Selected for cover Illustration).
112. Cappabianca P, Cinalli G, Gangemi M, Brunori A, Cavallo LM, de Divitiis E, Decq P, Delitala A, Di Rocco F, Frazee J, Godano U, Grotenhuis A, Longatti P, Mascari C, Nishihara T, Oi S, Rekate H, Schroeder HW, Souweidane MM, Spennato P, Tamburrini G, Teo C, Warf B, Zymberg ST. Application of neuroendoscopy to intraventricular lesions. Neurosurgery. 2008 Feb;62 Suppl2:575-97; discussion 597-8. doi: 10.1227/01.neu.0000316262.74843.dd.
113. Souweidane MM. Endoscopic surgery for intraventricular brain tumors in patients without hydrocephalus. Neurosurgery. 2008 Jun;62(6 Suppl 3):1042-8. doi: 10.1227/01.neu.0000333769.51069.80.
114. Souweidane MM. Pontine tumors. J Neurosurg Pediatr. 2008 May;1(5):424; author reply 424-5.
115. Worgall S, Sondhi D, Hackett NR, Kosofsky B, Kekatpure MV, Neyzi N, Dyke JP, Ballon D, Heier L, Greenwald BM, Christos P, Mazumdar M, Souweidane MM, Kaplitt MG, Crystal RG. Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. Hum Gene Ther. 2008 May;19(5):463-74. doi: 10.1089/hum.2008.022.
116. Hoffman CE, Souweidane MM. Cerebrospinal fluid-related complications with autologous duraplasty and arachnoid sparing in type I Chiari malformation. Neurosurgery. 2008 Mar;62(3 Suppl 1):156-60; discussion 160-1. doi: 10.1227/01.neu.0000317387.76185.ac.
117. Greenfield JP, Ayuso-Sacido A, Schwartz TH, Pannullo S, Souweidane M, Stieg PE, Boockvar JA. Use of human neural tissue for the generation of progenitors. Neurosurgery. 2008 Jan;62(1):21-37; discussion 27-30. doi: 10.1227/01.NEU.0000311059.87873.46.
118. Kramer K, Humm JL, Souweidane MM, Zanzonico PB, Dunkel IJ, Gerald WL, Khakoo Y, Yeh SD, Yeung HW, Finn RD, Wolden SL, Larson SM, Cheung NK. Phase I study of targeted radiommunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8. J Clin Oncol. 2007 Dec 1;25(34):5465-70.
119. Worgall S, Kekatpure MV, Heier L, Ballon D, Dyke JP, Shungu D, Mao X, Kosofsky B, Kaplitt MG, Souweidane MM, Sondhi D, Hackett NR, Hollmann C, Crystal RG. Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology. 2007 Aug 7;69(6):521-35.
120. Yoffe R, Khakoo Y, Dunkel IJ, Souweidane M, Lis E, Sklar C. Recurrent ependymoma treated with high-dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary-ovarian axis. Pediatr Blood Cancer. 2007 Oct 15;49(5):758-60.
121. Souweidane MM, Luther N. Endoscopic resection of solid intraventricular brain tumors. J Neurosurg. 2006 Aug;105(2):271-8.
122. Luther N, Edgar MA, Dunkel IJ, Souweidane MM. Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors. J Neurooncol. 2006 Aug;79(1):45-50.
123. Greenfield JP, Souweidane MM. Endoscopic management of intracranial cysts. Neurosurg Focus. 2005 Dec 15;19(6):E7.
124. Souweidane MM. Endoscopic surgery for intraventricular brain tumors in patients without hydrocephalus. Neurosurgery. 2005 Oct;57(4 Suppl):312-8; discussion 312-8.
125. Arkin LM, Sondhi D, Worgall S, Suh LH, Hackett NR, Kaminsky SM, Hosain SA, Souweidane MM, Kaplitt MG, Dyke JP, Heier LA, Ballon DJ, Shungu DC, Wisniewski KE, Greenwald BM, Hollmann C, Crystal RG. Confronting the issues of therapeutic misconception, enrolment decisions, and personal motives in genetic medicine-based clinical research studies for fatal disorders. Hum Gene Ter. 2005 Sep;16(9):1028-36.
126. Luther N, Cohen A, Souweidane MM. Haemorrhagic sequelae from intracranial neuroendoscopic procedures for intraventricular tumors. Neurosurg Focus. 2005 Jul15;19(1):E9.
127. Souweidane MM. Endoscopic management of pediatric brain tumors. Neurosurg Focus. 2005 Jun15;18(6A).
128. Dunkel IJ, Souweidane MM. Brain Stem Tumors. Curr Treat Options Neurol. 2005 Jul;7(4):315-321.
129. Narayana A, Bhatia S, Souweidane M, Khakoo Y, Zaider M. (32)P radioisotope therapy for recurrent pilocytic astrocytoma. Brachytherapy. 2005;4(2):17-3
130. Placantonakis DG, Ney G, Edgar M, Souweidane M, Hosain S, Schwartz TH. Neurosurgical management of medically intractable epilepsy associated with hypomelanosis of Ito. Epilepsia. 2005 Feb;46(2):329-31.
131. Crystal RG, Sondhi d, Hackett NR, Kaminsky SM, Worgall S, Stieg P, Souweidane M, Hosain S, Heier L, Ballon D, Dinner M, Wisniewski K, Kaplitt M, Greenwald BM, Howell JD, Strybing K, Dyke J, Voss H. Clinical protocol Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis. Hum Gene Ther. 2004 Nov;15(11):1131-54.
132. Badie B, Brooks N, Souweidane MM. Endoscopic and minimally invasive microsurgical approaches for treating brain tumor patients. J Neurooncol. 2004 Aug-Sep;69(1-3);2019-19.
133. Zonenshayn M, Kronberg E, Souweidane MM. Cranial index of symmetry: an objective semiautomated measure of plagiocephaly. Technical note. J Neurosurg. 2004 May;100(5 Suppl Pediatrics):537-40.
134. Wang JC, Heier L, Souweidane MM. Advances in the endoscopic management of Suprasellar arachnoid cysts in children. J Neurosurg. 2004 May;100(5 Suppl Pediatrics):418-26.
135. Rutka JT, Souweidane M, ter Brugge K, Armstrong D, Zuker R, Clarke H, Creighton R, McLeod E, Khoury A, Hoffman HJ. Separation of craniopagus twins in the era of modern neuroimaging interventional neuroradiology, and frameless Stereotaxy. Childs Nerv Syst. 2004 Aug;20(8-9):587-92.
136. Souweidane MM, Occhiogrosso G, Mark EB, Edgar MA, Dunkel IJ. Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine. J Neurooncol. 2004 May;76(3):319-26.
137. Souweidane MM, Occhiogrosso G, Mark EB, Edgar MA. Interstitial infusion of IL13-PE38QQR in the rat brain stem. J Neurooncol. 2004 May;67(3):287-93.
138. Sandberg DI, Bilsky MH, Kushner BH, Souweidane MM, Kramer K, Laquaglia MP, Panageas KS, Cheung NK. Treatment of spinal involvement in neuroblastoma patients. Pediatr Neurosurg. 2003 Dec;39(6):291-8.
139. Wolden SL, Dunkel IJ, Souweidane MM, Happersett L, Khakoo Y, Schupak K, Lyden D, Leibel SA. Patterns of failure using a conformal radiation therapy tumor bed boost for medulloblastoma. J Clin Oncol. 2003 Aug 15;21(16):3079-83.
140. Ulug AM, Truong TN, Filippi CG, Chun T, Lee JK, Yang C, Souweidane MM, Zimmerman RD. Diffusion imaging in obstructive hydrocephalus. AJNR AM J Neuroradiol. 2003 Jun-Jul;24(6):1171-6.
141. Occhiogrosso G, Edgar MA, Sandberg DI, Souweidane MM. Prolonged convection-enhanced delivery into the rat brainstem. Neurosurgery. 2003 Feb;52(2):388-93; discussion 393-4.
142. Sandberg DI, Edgar MA, Souweidane MM. Effect of hyperosmolar mannitol on convection-enhanced delivery into the rat brain stem. J Neurooncol. 2002 Jul;58(3):187-92.
143. Souweidane MM. Symptomatic spinal intradural arachnoid cysts in pediatric patients. Pediatr Neurosurg. 2002 Jul;37(1):56.
144. Antunes NL, Wolden S, Souweidane MM, Lis E, Rosenblum M, Steinherz PG. Radiation myelitis in a 5-year-old girl. J Child Neurol. 2002 Mar;17(3):217-9.
145. Sandberg DI, Edgar MA, Souweidane MM. Convection-enhanced delivery into the rat brainstem. J Neurosurg. 2002 May;96(5):885-91.
146. Antunes NL, Souweidane MM, Lis E, Rosenblum MK, Steinherz PG. Methotrexate leukoencephalopathy presenting as Kluver-Bucy syndrome and uncinated seizures. Pediatr Neurol. 2002 Apr;26(4):305-8.
147. Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL. Delayed surgical resection of central nervous system germ cell tumors. Neurosurgery. 2002 Apr;50(4):727-33; discussion 733-4.
148. Sugiltzoglu MK, Souweidane MM. Early management of craniocerebral injury with avoidance of post-traumatic leptomeningeal cyst formation. Report of two cases. Pediatr Neurosurg. 2001 Dec;35(6):329-33.
149. Horska A, Ulug AM, Melhem ER, Filippi CG, Burger PC, Edgar MA, Souweidane MM, Carson BS, Barker PB. Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Magn Reason Imaging. 2001 Jul;14(1):78-82.
150. Sandberg DI, Edgar MA, Resch L, Rutka JT, Becker LE, Souweidane MM. MIB-1 staining index of pediatric meningiomas. Neurosurgery. 2001 Mar;48(3):590-5; discussion 595-7.
151. Souweidane MM, Sandberg Di, Bilsky MH, Gutin PH. Endoscopic biopsy for tumors of the third ventricle. Pediatr Neurosurg. 2000 Sep;33(3):132-7.
152. Antunes NL, Boulad F, Prasad V, Rosenblum M, Lis E, Souweidane M. Rolandic encephalopathy and Epilepsia partialis continua following bone marrow transplant. Bone Marrow Transplant. 2000 Oct;26(8):917-9.
153. Hirsch J, Ruge MI, Kim KH, Correa DD, Victor JD, Relkin NR, Labar DR, Krol G, Bilsky MH, Souweidane MM, DeAngelis LM, Gutin PH. An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery. 2000 Sep;47(3):711-21; discussion 721-2.
154. Sandberg DL, Bilsky MH, Souweidane MM, Bzdil J, Gutin PH. Ommaya reservoirs for the treatment of leptomeningeal metastases. Neurosurgery. 2000 Jul;47(1):49-54; discussion 54-5.
155. Kramer K, Cheung NK, Humm JL, Dantis E, Finn R, Yeh SJ, Antunes NL, Dunkel IJ, Souweidane M, Larson SM. Targeted radiommunotherapy for leptomeningeal cancer using (131)I-3F8. Med Pediatr Oncol. 2000 Dec;35(6):716-8.
156. Sandberg DI, Souweidane MM. Hemifacial spasm caused by a pilocytic astrocytoma of the fourth ventricle. Pediatr Neurol. 1999 Oct;21(4):754-6.
157. Souweidane MM, Johnson JH Jr, Lis E. Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. J Neurooncol. 1999 Jun;43(2):167-71.
158. Antunes NL, Tavora L, Souweidane M. Globular glioma of the tectum. Pediatr Neurol. 1999 Jul;21(1):492-5.
159. Sandberg DI, Souweidane MM. Endoscopic-guided proximal catheter placement in treatment of posterior fossa cysts. Pediatr Neurosurg. 1999 Apr;30(4):180-5.
160. Souweidane MM, Kim KH, McDowall R, Ruge MI, Lis E, Krol G, Hirsch J. Brain mapping in sedated infants and you8ng children with passive-functional magnetic resonance imaging. Pediatr Neurosurg. 1999 Fev;30(2):86-92.
161. Souweidane MM, Bouffet E, Finlay J. The role of chemotherapy in new diagnosed ependymoma of childhood. Pediatr Neurosurg. 1998 May;25(5):273-8.
162. Souweidane MM, Drake JM. Retethering of sectioned fibrolipomatous filum terminals: report of two cases. Neurosurgery. 1998 Jun;42(6):1390-3.
163. Souweidane MM, Hoffman HJ. Current treatment of thalamic gliomas in children. J Neurooncol. 1996 Mya-Jun;28(2-3):157-66.
164. Souweidane MM, Benjamin V. Spinal cord meningiomas. Neurosurg Clin N Am. 1994 Apr;5(2):283-91.

2. Reviews, Letters, and Editorials

1. Janju MB, Caruso JP, Greenfield JP, Souweidane MM, Schwartz TH. The combined Transpetrosal Approach: Anatomic study and literature review. J Clin Neurosci. 2017. Jul:41:36-40. Doi: 10.1016/j.jcon.2017.03.015
2. Abdel Latif AM, Souweidane MM. Letter to the Editor: Asymptomatic lipomas of the conus medullaris. J Neurosurg Pediatr. 2015 Jul;16(1):112-3. Doi: 10.3171/2014.12.PEDS14668.
3. Souweidane MM. Editorial: Combined choroid plexus coagulation and endoscopic third ventriculostomy: is North America ready? Response. J Neurosurg Pediatr. 2014 Sep;14(3),221-3. Doi: 10.3171/2014.4.PEDS1450
4. Souweidane MM. Editorial: convection-enhanced delivery for diffuse intrinsic pontine glioma. J Neurosurg Pediatr. 2014 Mar;13(3):273-4. Doi: 10.3171/2013.10.PEDS13421
5. Kandasamy J, Souweidane M. Editorial: arachnoid cysts. J Neurosurg Pediatr. 2012 Mar;9(3):228-9; discussion 229-30. Doi: 10.3171/2011.11.PEDS11411.
6. Souweidane MM: Chiari Malformation Type I (Comment) J. Neurosurg Spine 6:727-8, 2010.
7. Souweidane MM: Anterior Third Ventriculostomy: an endoscopic variation on a theme (Comment) J Neurosurg 113(6):1259-60. 2010
8. Souweidane MM: Germ Cell Tumors. (Editorial Response) J Neurosurg Pediatrics 6:124, 2010.
9. Souweidane MM: Posterior Fossa Syndrome (Editorial) J Neurosurg Pediatrics 5(4):325-326. 2010.
10. Souweidane MM: Intraoperative Magnetic Resonance Imaging. (Editorial) J Neurosurg Pediatrics 4(5):465, 2009.
11. Dunkel IJ, Souweidane MM: Pontine Glioma (Editorial) J Neurosurg Pediatrics 3:257-258, 2009.
12. Souweidane MM: Endoscopic Stomy of the Septum Pellucidum: Indications, Techniques, and Results. (Comment). Neurosurgery 64(3):492. 2009.
13. Souweidane MM: Efficacy of endoscopic third ventriculostomy in fourth ventricular outlet obstruction (Comment) Neurosurgery 63(5):914. 2008.
14. Souweidane MM: Purely Endoscopic Resection of Colloid Cysts. (Comment) Neurosurgery 62[ONS Suppl 1}: 55. 2008.
15. Souweidane MM: Laser-Assisted Endoscopic Third Ventriculostomy: Long-Term results in a series of 202 Patients. (Comment) Neurosurgery 62(2):443-444. 2008.
16. Stieg PE, Souweidane MM: Clinical Problem Solving: family Matters. (Comment) Neurosurgery 62(1):200-201. 2008.
17. Souweidane MM: Pontine Tumors. (Editorial) J Neurosurg Pediatrics. May; 1(5):424. 2008.
18. Souweidane MM: the history of Neurosurgery at the Hospital for Sick Children in Toronto. (Comment) Neurosurgery 61(3):624. 2007.
19. Souweidane MM: Freehand Dynamic Endoscopic Resection of an Epidermoid Tumor of the Cerebellopontine Angle: Technical Case Report (Comment) Neurosurgery 61[ONS Suppl 2}:239-240. 2007.
20. Souweidane MM: Endoscopic Third Ventriculostomy in Pediatric Patients: The Canadian Experience (Comment) Neurosurgery 60(5):885. 2007.
21. Souweidane MM: Long-Term Results and Late Complications after Intracavitary Yttrium-90 Colloid Irradiation of Recurrent Cystic Craniopharyngiomas. Neurosurgery 61(2):296. 2007.
22. Souweidane MM: Laparoscopic Peritoneal Catheter Placement: Results of a New Method in 111 Patients. (comment) Neurosurgery 61[ONS Suppl 1}:172-173. 2007.
23. Souweidane MM: Endoneurosonography: Technique and Equipment, Anatomy and Imaging, and Clinical Application. (Comment) Neurosurgery 61[ONS Suppl 1}:159. 2007.
24. Souweidane MM: Endoscopic Anatomy of the Cerebral Aqueduct. (Comment). Neurosurgery 61 {ONS Suppl 1}:1. 2007.
25. Souweidane MM: Stereotactic Volumetric Resection of Thalamic Pilocytic Astrocytomas. (Comment) Neurosurgery 61:75. 2007.
26. Souweidane MM: Treatment Options for Third Ventricular Colloid Cysts: Comparison of Open Microsurgical Versus Endoscopic Resection. (Comment). Neurosurgery 60:619. 2007.
27. Souweidane MM: Endoscopic transaqueductal Removal of Fourth Ventricular Neurocysticercosis with an Angiographic Catheter. (Comment) Neurosurgery 60 [ONS Suppl 2}:254. 2007
28. Souweidane MM: Complete microsurgical Resection of Colloid Cysts with a Dual-Port Endoscopic Technique. (Comment) Neurosurgery 60 [ONS Suppl 1]:42. 2007.
29. Souweidane MM: Endoscopic Third Ventriculostomy for Occlusive Hydrocephalus Caused by Cerebellar Infarction. (Comment) Neurosurgery 59(3):543. 2006.
30. Souweidane MM: Endoscopically-Assisted Resection of a Choroid Plexus Vascular Malformation Traversing the Cerebral Aqueduct: Technical Case Report. (Comment). Neurosurgery 58 [ONS Suppl 2]:378. 2006.
31. Souweidane MM: Simultaneous Image-Guided and Endoscopic Navigation without Rigid Cranial Fixation: Application in Infants: Technical Case Report. (Comment). Neurosurgery 58 [ONS Suppl 2}:378. 2006
32. Souweidane MM: Polymerase Chain Reaction for the Rapid Detection of Cerebrospinal Fluid Shunt or Ventriculostomy Infections. (Comment) Neurosurgery 57:1242. 2005.
33. Souweidane MM: Local and Sustained Delivery of 5-Fluorouracil from Biodegradable Microspheres for the Raiosensitization of Malignant Gliomas: A Randomized Phase II Trial. (Comment) Neurosurgery 56:247-248. 2005.
34. Gutin PH, Souweidane MM: The Role of Radiosurgery for the Treatment of Pineal Parenchymal tumors. (Comment). Neurosurgery 51:888-889. 2002.
35. Souweidane MM: Symptomatic Spinal Intradural Arachnoid Cysts in Pediatric Patients. (letter) Pediatr Neurosurg 37:56. 2002.
36. Gutin PH, Souweidane MM: Radiosurgery for Childhood Intracranial Arteriovenous Malformations. (Comment) Neurosurgery 47:842. 2000.
37. Souweidane MM: Adult Medulloblastoma: Prognostic Factors and Patterns of Relapse. (Comment) neurosurgery 47:631-632.2000.

Video:

The director of pediatric neurosurgery at the Weill Cornell Brain and Spine Center talks about the challenges and rewards of his work - both clinical and research - in treating children with disorders of the brain and spine.

Dr. Mark Souweidane: Pediatric Neurosurgery, 2013

Educational Background:

Internship: University of Michigan

Residency: New York University

Fellowship: Hospital for Sick Children


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Additional Locations

Memorial Sloan-Kettering Cancer Center

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