Doctor Profile

Jeffrey P. Greenfield
MD

Jeffrey Greenfield
MD

New York

New York (NY)

Neurological Surgery
Doctor's practice has a pediatric specialty or subspecialty

Neurological Surgery


Profile

Dr. Greenfield is a board-certified neurosurgeon who specializes in pediatric neurosurgery. In addition he sees certain adult patients with congenital neurosurgical conditions. Compassionate clinical care, research, and education are all central to his philosophy as a neurosurgeon and physician.

As creator and director of the Chiari CARE program, Dr. Greenfield has developed an international reputation caring for children and adults with Chiari malformation, tethered cord, syringomyelia, and other associated conditions such as craniocervical instability, CSF leaks, and hydrocephalus as part of a large multidisciplinary team. Dr. Greenfield is a strong proponent of the unique concept of transitional neurosurgery – caring for patients with specific conditions from childhood through adulthood.

Dr. Greenfield also directs the pediatric skull base surgery program, evaluating and removing tumors of the pituitary gland region and skull base such as craniopharyngiomas with minimally invasive endoscopic tools. Dr. Greenfield is also expert in utilizing minimally invasive ventricular endoscopy of the brain to treat tumors, hydrocephalus, and cysts within the ventricles, and intraoperative brain and spine mapping and imaging to care for children with benign and malignant tumors of the brain and spine.

Dr. Greenfield is co-author of Common Neurosurgical Conditions in the Pediatric Practice: Recognition and Management, recently published by Springer.

Dr. Greenfield graduated from Amherst College magna cum laude in Neuroscience before receiving his M.D. and Ph.D. degrees from the Weill Medical College of Cornell University. Following completion of his neurosurgical residency and chief residency at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, Dr. Greenfield received further training in surgical treatment of brain tumors, epilepsy, spinal dysraphism, complex spinal column injury, spinal cord tumors, and fetal surgery for myelomeningocoele at The Children’s Hospital of Philadelphia.

In addition to his clinical activities, Dr. Greenfield’s directs multiple research projects pertaining to pediatric brain tumors, in particular, basic research examining the brain tumor microenvironment, tumor immunology, and precision medicine. This research has been externally funded and widely published and he has received national awards from neurosurgical societies. He has lectured internationally on these subjects and together with Dr. Mark Souweidane he co-directs the Children’s Brain Tumor Project, focusing on novel approaches and innovative care for children with rare and inoperable brain tumors.

Teaching and education are also central to Dr. Greenfield’s career in neurosurgery. As associate program director for the residency program in neurological surgery, he has won multiple teaching awards from the residents, and recently designed a novel curriculum to augment their seven-year training. He directs the medical student interest groups and the rotations for medical students on the neurosurgery service. Finally, he recently co-edited a textbook with a pediatrician designed to facilitate the education of primary care providers of children with the common neurosurgical conditions they may see in their practice.

Published In:

New York Super Doctors 2020
New York Super Doctors 2019
New York Super Doctors 2018
New York Super Doctors 2017
New York Rising Stars 2015

About Jeffrey Greenfield

Medical School: Cornell University, Joan & Sanford I. Weill Medical College

Graduation Year: 2002

Professional Webpage: weillcornell.org/physician/jpgreenfield/

Honors and Awards:

Pediatric Brain Tumor Award, AANS/CNS Section on Tumors, 2018

Attending Teaching Award, House Staff, Weill Cornell Medical College, 2010,

Attending Teaching Award, House Staff, Weill Cornell Medical College, 2017

Attending Teaching Award, House Staff, Weill Cornell Medical College, 2014

Attending Teaching Award, House Staff, Weill Cornell Medical College, 2010

Distinguished House Staff Award, New York Weill Cornell Medical Center Alumni Council, 2007

Shulman Award for Outstanding Resident Presentation, National Pediatric Section, AANS, 2007

Outstanding Resident Presentation, New York Neurosurgery Society, 2006

Award for Outstanding Resident Presentation, Hydrocephalus Association, 2005

Harold Wolff Neuroscience Research Prize, Cornell Medical School, 2002

Community Service:

"Pediatric TBI" lecture and local staff training at "First Hands-on Neurotrauma Course for the East, Central, and Southern African Regions;" course conducted in Dar es Salaam, Tanzania, as part of Weill Cornell's Neurosurgical Mission in Tanzania.

2014

Publications, Lectures and Presentations:

Articles in Professional Peer-Reviewed Journals

1. Greenfield JP, Gouras GK, Xu H. Cellular and molecular basis of beta-amyloid precursor protein metabolism. Front Biosci 26;3:399-407, 1998.

2. Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4:447-51, 1998.

3. Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A 96:742-7, 1999.

4. Greenfield JP, Xu H, Greengard P, Gandy S, Seeger M. Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein. J Biol Chem 274:33843-6, 1999.

5. Gouras GK, Naslund J, Vincent B, Checler F, Greenfield JP, Buxbaum JD, Xu H, Greengard P, Relkin NR. Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 156:15-20, 2000.

6. Gouras GK, Xu H, Gross RS, Greenfield JP, Hai B, Wang R, Greengard P. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A 97:1202-5, 2000.

7. Greenfield JP, Gross RS, Gouras GK, Xu H. Cellular and molecular basis of beta-amyloid precursor protein metabolism. Front Biosci 5:72-83, 2000.

8. Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem 277:12128-36, 2002.

9. Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem 278:3446-54, 2003.

10. Greenfield JP, & Bilsky MH. Neurosurgical interventions for leptomeningeal tumor. Canc Treat Res 125:107-19, 2004.

11. Greenfield JP, & Souweidane MM. Endoscopic Management of Intracranial Cysts. Neurosurg Focus;19, 2005.

12. Luther N, Greenfield JP, Chadburn A, Schwartz TH. Intracranial Nasal Natural Killer/T-cell Lymphoma: Immunopathologically-Confirmed Case and Review of Literature. J Neurooncol. 75(2):185-8, 2005.

13. Ayuso-Sacido A, Greenfield JP, Boockvar JA. The Duality of Epidermal Growth Factor Receptor (EGFR) Signaling and Neural Stem Cell Phenotype: Cell Enhancer or Cell Transformer. Curr Stem Cell Res & Ther,1, 387-94, 2006.

14. Greenfield JP, Schwartz TH. Catheter placement for Ommaya reservoirs with frameless surgical navigation: technical note. Stereotact Funct Neurosurg 86(2):101-5, 2007.

15. Gologorsky Y, DeLaMora P, Greenfield JP, Souweidane MM. Cerebellar Cryptococcoma in an Immunocompetent Child Mimicking a Juvenile Pilocytic Astrocytoma. J. Neurosurg 107:314-7, 2007.

16. Greenfield JP, Ayuso-Sacido A, Schwartz TH, Pannullo S, Souweidane M, Stieg PE, Boockvar JA. Use of human neural tissue for the generation of progenitors. Neurosurgery 62(1):21-37, 2008.

17. Ayuso-Sacio A, Roy NS, Schwartz TH, Greenfield JP, Boockvar JA. Long term expansion of adult human brain subventricular zone precursors. Neurosurgery 62(1):223-9; 2008.

18. Bleau A-M, PhD, Howard, BM, Taylor LA, Gursel D, Greenfield JP, Tung YH, Holland EC, Boockvar JA. A new strategy for analysis of phenotypic marker antigens in murine and human brain tumor derived neurospheres, Neurosurg Focus. 24(3-4):E28, 2008.

19. Laufer I, Greenfield JP, Anand VK, Hartl R. Endonasal Endoscopic Resection of the Odontoid in a Non-Achondroplastic Dwarf with Rheumatoid Arthritis. Feasibility of the Approach and Utility of Intraoperative Iso-C 3D Navigation. J Neurosurg Spine 8(4):376-80, 2008.

20. Greenfield JP, Howard BM, Huang C, Boockvar JA. Endoscopic endonasal transphenoidal surgery using a skull reference array and laser surface scanning. Minim Invas Neurosurg, 51(4):244-6, 2008.

21. Greenfield JP, Cobb W, Tsouiris AJ, Schwartz TH. Stereotactic Minimally Invasive Tubular Retractor System for Deep Brain Lesions, Neurosurgery, Oct;63(4 Suppl 2):334-9; discussion 339-40, 2008.

22. Greenfield JP, Hoffman CE, Kuo E, Christos PJ, Souweidane MM. Intraoperative Assessment of Endoscopic Third Ventriculostomy Success, J Neurosurg Pediatrics. 2(5):298-303, 2008.

23. Greenfield JP, Leng L, Chaudhry U, Anand V, Brown S, Souweidane MM, Schwartz TH. Combined Simultaneous Endoscopic Transsphenoidal and Endoscopic Transventricular Resection of a Giant Pituitary Macroadenoma, Minim Invas Neurosurg, 51(5):306-9, 2008.

24. Greenfield JP, Jin DK, Young LM, Christos PJ, Abrey L, Rafii S, Gutin PH. Surrogate Markers Predict Angiogenic Potential and Survival in Patients with Glioblastoma Multiforme, Neurosurgery. 2009 May; 64 (5): 819-26; discussion 826-7.

25. Greenfield JP, Anand V, Kacker A, Seibert M, Singh A, Brown S, Schwartz TH. Endoscopic Endonasal Transethmoidal Transcribriform Transfovea Ethmoidalis Approach to the Anterior Cranial Fossa and Skull Base, Neurosurgery Volume 66, 5, 883-92. Discussion 892. May, 2010.

26. Greenfield JP, Riina H, Fralin S, Gobin Y.P., Tsiouris A.J., Souweidane M.M.S., Boockvar J.A. Balloon-Assisted Supeselective Intra-Arterial Cerebral Infusion of Bevacizumab for Malignant Brainstem Glioma- A Technical Note, Interventional Neuroradiology, 16.1, 71-6, March 16, 2010.

27. Greenfield JP, Cobb WS, Lyden D. Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas. J Clin Invest. 2010 Mar; 120(3):663-7.

28. Kasliwal MK, Fraser JF, Greenfield JP, Schwartz TH. Simultaneous middle fossa arachnoid cyst and ambient cistern epidermoid cyst: case report and endoscope-assisted microsurgical management. Pediatr Neurosurg. 2010 Aug;46(2):151-4.

29. Rubin D, Santillan A, Greenfield JP, Souweidane MM, Riina HA. Surgical Management of pediatric cerebral arteriovenous malformations, Childs Nerv Syst. 2010 Oct; 26(10): 1337-44.

30. Woodworth GF, McCoul E, Anand VK, Greenfield JP, Schwartz TH. Endoscopic management of anterior cranial fossa meningiomas. Operative Techniques in Otolaryngology. 2011 Dec; Vol 22, 254-262. (Listed as Greenfield JF on PubMed author error).

31. Gürsel DB, Beyene RT, Hofstetter C, Greenfield JP, Souweidane MM, Kaplitt M, Arango-Lievano M, Howard B, Boockvar JA. Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction. J Neurooncol. 2011 Sep; 104(2): 509-22.

32. Morgenstern PF, Osbun N, Schwartz TH, Greenfield JP, Tsiouris AJ, Souweidane MM. Pineal region tumors: an optimal approach for simultaneous endoscopic third ventriculostomy and biopsy. Neurosurg Focus. 2011 Apr;30(4):E3.

33. Leng, LZ, Greenfield JP, Souweidane MM; Anand, VK, Schwartz TH. Endoscopic, endonasal resection of craniopharyngiomas: analysis of outcome including extent of resection, cerebrospinal fluid leak, return to preoperative productivity, and body mass index. Neurosurgery. 2012 Jan;70(1):110-23; discussion 123-4.

34. Rajappa P, Krass J, Riina HA, Boockvar JA, Greenfield JP. Super-Selective Basilar Artery Infusion of Bevacizamab and Cetuximab for Multiply Recurrent Pediatric Ependymoma. Interv Neuroradiol. 2011 Dec; 17(4):459-65.

35. Allen BB, Hoffman CE, Traube CS, Weinstein SL, Greenfield JP. Continuous Brain Tissue Oxygenation Monitoring in the Management of Pediatric Stroke. Neurocrit Care. 2011 Dec;15(3):529-36.

36. Kramer K, McCrea HJ, Fischer C, Greenfield JP. Establishing Successful cerebrospinal fluid flow for radioimmunotherapy. J Neurosurg Pediatr. 2012 Mar;9(3):316-9.

37. McCrea HJ, Knopman J, Engel M, Riina HA, Souweidane MM, Schwartz TH, Greenfield JP. Concurrent anatomic hemispherectomy and thalamic arteriovenous malformation resection. Childs Nerv Syst. 2012 Aug;28(8):1273-7.

38. Lancman G, Virk M, Shao H, Mazumdar M, Greenfield JP, Weinstein S, Schwartz TH. Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox-Gastaut syndrome: A meta-analysis. Seizure. 2013 Jan;22(1):3-8.

39. Kim JH, Huse JT, Huang Y, Lyden D, Greenfield JP. Molecular diagnostics in paediatric glial tumours. Lancet Oncol. 2013 Jan;14(1):e17-27.

40. Kim JH, Huang Y, Griffin AS, Rajappa P, Greenfield JP. Ependymoma in children: molecular considerations and therapeutic insights. Clin Transl Oncol. 2013 Oct; 15(10): 759-65.

41. Rajappa P, Margetis K, Sigounas D, Anand V, Schwartz TH, Greenfield JP. Endoscopic Endonasal Trans-Clival Approach to a Ventral Pontine Ependymoma. J Neurosurg Pediatr. 2013 Nov;12(5):465-8.

42. Allen BB, Chiu YL, Gerber LM, Ghajar J, Greenfield JP. Age-Specific Cerebral Perfusion Pressure Thresholds and Mortality in Children and Adolescents with Severe Traumatic Brain Injury. Pediatr Crit Care Med. 2014 Jan; 15(1):62-70.

43. Huang Y, Hoffman C, Rajappa P, Kim JH, Hu W, Huse JT, Tang Z, Li X, Weksler B, Bromberg J, Lyden D, Greenfield JP. Oligodendrocyte progenitor cells promote neo-vascularization in glioma by disrupting the blood brain barrier. Cancer Res. 2014 Feb 15; 74(4): 1011-21.

44. Banu MA, Guerrero-Maldonado A, McCrea HJ, Garcia-Navarro V, Souweidane MM, Anand VK, Heier L, Schwartz TH, Greenfield JP. Impact of skull base development on endonasal endoscopic surgical corridors. J Neurosurg Pediatr. 2014 Feb;13(2):155-69.

45. Krass J, Rajappa P, Parakh S, Spinelli HM, Greenfield JP. An Aesthetic Approach to the Anterior Cranial Fossa: The Endoscopic Transadnexal Transorbital Roof Method. Aesthetic Plast Surg. 2014 Apr;38(2):399-403.

46. Tong WY, Folkert MR, Greenfield JP, Yamada Y, Wolden SL. Intraoperative phosphorus-32 brachytherapy plaque for multiply recurrent high-risk epidural neuroblastoma. J Neurosurg Pediatr. 2014 Apr;13(4):388-92.

47. Allen BB, Greenfield JP. The authors reply. Pediatr Crit Care Med. 2014 May;15(4):388-9.

48. George E, Heier L, Kovanlikaya I, Greenfield JP, Diffusion tensor imaging of pyramidal tract reorganization after pediatric stroke. Childs Nervous System. 2014 Jun;30(6):1135-9.

49. Banu MA, Rathman A, Patel KS, Souweidane MM, Anand VK, Greenfield JP, Schwartz TH. Corridor-based endonasal endoscopic surgery for pediatric skull pathology with detailed radioanatomic measurements. Neurosurgery. 2014 Jun;10 Suppl 2:273-93; discussion 293.

50. Iorgulescu B, Souweidane MM, Greenfield JP, Parsa AT. 182 Pediatric Craniotomies: Incidence, Predictors, and Costs for a Tristate Analysis with 1-Year Readmission Follow-up. Neurosurgery. 2014 Aug;61 Suppl 1:220.

51. Grinspan ZM, Pon S, Greenfield JP, Malhotra S, Kosofsky BE. Multimodal monitoring in the pediatric intensive care unit: new modalities and informatics challenges. Semin Pediatrc Neurol. 2014 Dec;21(4):291-8.

52. Margetis K, Rajappa P, Tsiouris JA, Greenfield JP, Schwartz TH. Intraoperative stereotactic injection of Indigo Carmine dye to mark ill-defined tumor margins. A prospective phase 1-2 study. Neurosurg 2015 Jan; 122(1): 40-8.

53. Goldschlager T, Hartl, R, Greenfield JP, Anand VK, Schwartz TH. The endoscopic endonasal approach to the odontoid and its impact on early extubation and feeding. J Neurosurg. 2015 Mar; 122(3):511-8.

54. La Corte E, Aldana, PR, Ferroli P, Greenfield JP, Hartl R, Anand VK, Schwartz TH. The rhinopalatine line as a reliable predictor of the inferior extent of endonasal odontoidectomies. Neurosurg Focus. 2015 Apr; 38(4): E16.

55. Patel KS, Raza SM, McCoul ED, Patrona A, Greenfield JP, Souweidane MM, Anand VK, Schwartz TH. Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas. J Neurosurg. 2015 Apr;1-10.

56. Papaspyriodonos M, Matei I, Huang Y, do Rosario Andre M, Brazier-Mitouart H, Waite JC, Chan AS, Kalter J, Ramos I, Wu Q, Williams C, Wolchok JD, Chapman PB, Peinado H, Anandasabarpathy N, Ocean AJ, Kaplan RN, Greenfield JP, Bromberg J, Skokos D, Lyden D. Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation. Nat Commun. 2015 Apr;6:6840.

57. Xu R, McCrea HJ, Hoffman C, Souweidane MM, Greenfield JP. The impact of endoscopic third ventriculostomy on shunt revision rate: a 14-year experience at a single institution. World Neurosurg. 2015 Sep;84(3), 677-80.e1. doi: 10.1016/j.wneu.2015.04.037.

58. McCrea HJ, Bander ED, Venn RA, Reiner AS, Iorgulescu JB, Puchi LA, Schaefer PM, Cederquist G, Greenfield JP. Sex, Age, Anatomic Location, and Extent of Resection Influence Outcomes in Children With High-grade Glioma. Neurosurgery. 2015 Sep;77(3):443-52; discussion 452-3. doi: 10.1227/NEU.0000000000000845.

59. Behaine J, Abdel Latif AM, Greenfield JP. Fecal incontinence as a predominant symptom in a case of multiply recurrent tethered cord: diagnosis and operative strategies. J Neurosurg Pediatr. 2015 Dec;16(6):748-51. doi: 10.3171/2015.5.PEDS15124.

60. Xu R, Pisapia D, Greenfield JP. Malignant Transformation in Glioma Steered by an Angiogenic Switch: Defining a Role for Bone Marrow-Derived Cells. Cureus. 2016 Jan 27;8(1):e471. doi: 10.7759/cureus.471.

61. George E, Settler A, Connors S, Greenfield JP. Pediatric Gliomatosis Cerebri: A Review of 15 Years. J Child Neurol. 2016 Mar;31(3):378-87. doi: 10.1177/0883073815596612.

62. Michelson N, Rincon-Torroella J, Quiñones-Hinojosa A, Greenfield JP. Exploring the role of inflammation in the malignant transformation of low-grade gliomas. J Neuroimmunol. 2016 Aug 15;297:132-40. doi: 10.1016/j.jneuroim.2016.05.019.

63. Morgenstern PF, Connors S, Reiner AS, Greenfield JP. Image guidance for the placement of Ommaya reservoirs: A comparison of fluoroscopy and frameless stereotactic navigation in 145 patients. World Neurosurg. 2016 Sep;93:154-8. doi: 10.1016/j.wneu.2016.04.090.

64. McCrea HJ, George E, Settler A, Schwartz TH, Greenfield JP. Pediatric suprasellar tumors. J Child Neurol. 2016 Oct;31(12):1367-76. doi: 10.1177/0883073815620671.

65. Greenfield JP, Castañeda Heredia A, George E, Kieran MW, Morales La Madrid A. Gliomatosis cerebri: A consensus summary report from the First International Gliomatosis cerebri Group Meeting, March 26-27, 2015, Paris, France. Pediatr Blood Cancer. 2016 Dec;63(12):2072-7. doi: 10.1002/pbc.26169.

66. Vijay P, McIntyre AB, Mason CE, Greenfield JP, Li S. Clinical Genomics: Challenges and Opportunities. Crit Rev Eukaryot Gene Expr. 2016;26(2):97-113. doi: 10.1615/CritRevEukaryotGeneExpr.2016015724.

67. Dhandapani S, Singh H, Negm HM, Cohen S, Souweidane MM, Greenfield JP, Anand VK, Schwartz TH. Endonasal endoscopic reoperation for residual or recurrent craniopharyngiomas. J Neurosurg. 2017 Feb;126(2):418-30. doi: 10.3171/2016.1.JNS152238.

68. Janjua MB, Zhou PL, Greenfield JP, Baaj AA, Frempong-Boadu A. C2 and greater occipital nerve: The anatomic and functional implications in spinal surgery. Cureus. 2017 Mar 3;9(3):e1074. doi: 10.7759/cureus.1074.

69. Zhou Z, Luther N, Singh R, Boockvar JA, Souweidane MM, Greenfield JP. Glioblastoma spheroids produce infiltrative gliomas in the rat brainstem. Childs Nerv Syst. 2017 Mar;33(3):437-46. doi: 10.1007/s00381-017-3344-y.

70. Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May;127(5):1826-38. doi: 10.1172/JCI86443.

71. Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-generation rapid autopsies enable tumor evolution tracking and generation of preclinical models. JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.16.00038. Epub 2017 Jun 14.

72. Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells. Clin Cancer Res. 2017 Jun 15;23(12):3109-19. doi: 10.1158/1078-0432.CCR-16-1508.

73. Singh H, Rote S, Jada A, Bander ED, Almodovar-Mercado GJ, Essayed WI, Härtl R, Anand VK, Schwartz TH, Greenfield JP. Endoscopic endonasal odontoid resection with real-time intraoperative image-guided computed tomography: report of 4 cases. J Neurosurg. 2018 May;128(5):1486-1491

74. Janjua MB, Caruso JP, Greenfield JP, Souweidane MM, Schwartz TH. The combined transpetrosal approach: Anatomic study and literature review. J Clin Neurosci. 2017 Jul;41:36-40. doi: 10.1016/j.jocn.2017.03.015.

75. Janjua MB, Ivasyk I, Greenfield JP. Vertebrobasilar insufficiency due to distal posterior inferior cerebellar artery compression in Chiari 1.5. World Neurosurg. 2017 Jun 3. doi: 10.1016/j.wneu.2017.05.089.

76. Omay SB, Chen YN, Almeida JP, Ruiz-Treviño AS, Boockvar JA, Stieg PE, Greenfield JP, Souweidane MM, Kacker A, Pisapia DJ, Anand VK, Schwartz TH.Do craniopharyngioma molecular signatures correlate with clinical characteristics? J Neurosurg. 2018 May;128(5):1473-1478

77. Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV.A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma. Pediatr Blood Cancer. 2018 Jan;65(1)

78. Lange KR, Fischer C, Rajappa P, Connors S, Pisapia D, Greenfield JP, Beltran H, Rubin M, Mosquera JM, Khakoo Y. Rapid autopsy of a patient with recurrent anaplastic ependymoma. Palliat Support Care. 2018 April;16(2):238-242.

79. Alalade AF, Ogando-Rivas E, Boatey J, Souweidane MM, Anand VK, Greenfield JP, Schwartz TH. Suprasellar and recurrent pediatric craniopharyngiomas: expanding indications for the extended endoscopic transsphenoidal approach. J Neurosurg Pediatr. 2018 Jan;21(1):72-80.

80. Hussain I, Schwartz TH, Greenfield JP. Endoscopic Endonasal Approach to the Upper Cervical Spine for Decompression of the Cervicomedullary Junction Following Occipitocervical Fusion. Clin Spine Surg. 2018 Aug;31(7):285-292

81. Campbell C, Greenfield JP. Precision oncogenomics in pediatrics: a personal reflection. Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2).

82. Ottenhausen M, Alalade AF, Rumalla K, Nair P, Baaj A, Hartl R, Kacker A, Greenfield JP, Anand VK, Schwartz TH. Quality of Life After Combined Endonasal Endoscopic Odontoidectomy and Posterior Suboccipital Decompression and Fusion. World Neurosurg. 2018 Aug;116:e571-e576

83. Forbes JA, Banu M, Lehner K, Ottenhausen M, La Corte E, Alalade AF, Ordóñez-Rubiano EG, Greenfield JP, Anand VK, Schwartz TH. Endoscopic endonasal resection of epidermoid cysts involving the ventral cranial base. J Neurosurg. 2018 Jun 8:1-10.

84. Lara-Reyna J, Carlton J, Parker WE, Greenfield JP. Synchronous complex Chiari malformation and cleft palate-a case-based review. Childs Nerv Syst. 2018 Aug 21.

85. Ordóñez-Rubiano EG, Forbes JA, Morgenstern PF, Arko L, Dobri GA, Greenfield JP, Souweidane MM, Tsiouris AJ, Anand VK, Kacker A, Schwartz TH. Preserve or sacrifice the stalk? Endocrinological outcomes, extent of resection, and recurrence rates following endoscopic resection of craniopharyngiomas. J Neurosurg. 2018 Nov 1:1-9.

86. Weidman EK, Morgenstern PF, Phillips CD, Greenfield JP, Schwartz TH, Heier LA. Beals syndrome with middle and inner ear dysplasia and encephalocele: A case report and review of imaging findings. Int J Pediatr Otorhinolaryngol. 2019 Feb;117:26-29.

87. Janjua MB, Hwang SW, Samdani AF, Pahys JM, Baaj AA, Härtl R, Greenfield JP. Instrumented arthrodesis for non-traumatic craniocervical instability in very young children. Childs Nerv Syst. 2019 Jan;35(1):97-106. 88.

88. Martinez-Lage M, Lynch TM, Bi Y, Cocito C, Way GP, Pal S, Haller J, Yan RE, Ziober A, Nguyen A, Kandpal M, O'Rourke DM, Greenfield JP, Greene CS, Davuluri RV, Dahmane N. Immune landscapes associated with different glioblastoma molecular subtypes. Acta Neuropathol Commun. 2019 Nov 29;7(1):203. doi: 10.1186/s40478-019-0803-6.89.

89. Nisson PL, Link TW, Carnevale J, Virk MS, Greenfield JP. Primary Aneurysmal Bone Cyst of the Thoracic Spine: A Pediatric Case Report. World Neurosurg. 2019 Nov 1;134:408-414. doi: 10.1016/j.wneu.2019.10.151.

Textbooks edited

1. Common Neurosurgical Conditions in the Pediatric practice – Recognition and Management Editor: Greenfield JP and Long CB. September 2016.

2. Pediatric Endonasal Endoscopic Skull Base Surgery: A Case-Based Manual. Endo-Press 2016: Singh H, Greenfield JP, Anand VK, Schwartz TH.

3. Pediatric Endoscopic Endonasal Skull Base Surgery: Singh H, Greenfield JP, Anand VK, Schwartz TH. Thieme Due out Fall 2018


Book Chapters

1. Greenfield JP, and Bilsky MH. Neurosurgical interventions for leptomeningeal tumor. Leptomeningeal Metastasis. Abrey L, Ed. 2005

2. Greenfield JP, Anand V, and Schwartz TS. Peri-operative management of patients undergoing endoscopic skull base surgery. Practical Endoscopic Skull Base Surgery. Anand V and Schwartz TS, Ed. 2006

3. Greenfield JP, and Souweidane MM. Diagnosis and Management of Pediatric Arteriovenous Malformations. Intracranial Arteriovenous Malformations. Stieg PE, Ed. 2007

4. Greenfield JP, Anand V, and Schwartz TS. Neurocritical Care Management of Patients after Endonasal Endoscopic Transphenoidal Surgery. Endoscopic Skull Base Surgery, Schwartz TS, Ed. 2009

5. Greenfield JP, and Allen BB. Steroids and Pediatric Traumatic Brain Injury. Pediatric TBI Guidelines, Gajjar et al, Ed. 2011

6. Greenfield JP, and Schwartz TH. Postoperative and Neurocritical Care Management of Patients After Endonasal Endoscopic Transsphenoidal Pituitary Surgery, Endoscopic Pituitary Surgery, Schwartz TS, Ed. 2011

7. Greenfield JP, Souweidane MM, and Schwartz TS. Endoscopic Approach to Intraventricular Brain Tumors. Schmidek & Sweet Operative Neurosurgical techniques, ed 6 Quinones AH, Ed. 2011.

8. Greenfield JP et al. Bone Marrow-Derived Cells Support Malignant Transformation of Low-Grade Glioma. Glioma. Book 1. 2011.

9. Moliterno-Gunel J, Greenfield JP, Souweidane MM, and Schwartz, TS. Endoscopic Approach to Intraventricular Brain Tumors. Schmidek & Sweet Operative Neurosurgical techniques, ed 6 Quinones AH, Ed. 2013.

10. Cisse B, Hussain I, Greenfield JP, Long CB Birth Trauma to the Scalp and Skull in Common Neurosurgical Conditions in the Pediatric practice Ed. Greenfield JP and Long CB. Springer Publishers: September 2016

11. Beam CA, Berastegui RA, Greenfield JP. Evaluation of Head Shape in the Pediatric Practice: Plagiocephalus vs Craniosynostosis in Common Neurosurgical Conditions in the Pediatric practice Editors: Greenfield JP and Long CB. Springer Publishers: September 2016.

12. Margetis K, and Greenfield JP. Chiari Malformation in Common Neurosurgical Conditions in the Pediatric practice Editors: Greenfield JP and Long CB. Springer Publishers: September 2016.

13. Kimball D and Greenfield JP Assessment and Management of Minor Head Injurties in Toddlers and Adolescents Common Neurosurgical Conditions in the Pediatric practice. Editors: Greenfield JP and Long CB. Springer Publishers: September 2016.

14. Banu M, Greenfield JP, Anand VK, and Schwartz TH Anatomy of the Developing Pediatric Skull Base in Pediatric Endoscopic Endonasal Skull Base Surgery Editors: Singh H, Greenfield JP, Anand VK, Schwartz TH. Thieme 2019.

15. Forbes JA, Dobri G, Schwartz TH, and Greenfield JP Postoperative Care for Pediatric Skull Base Patients: The Neurosurgery Perspective, in Pediatric Endoscopic Endonasal Skull Base Surgery Editors: Singh H, Greenfield JP, Anand VK, Schwartz TH. Thieme 2019.


Invited Reviews

1. Greenfield, JP, Boockvar, JA. Patient derived embryonic stem cells. Science Times, Neurosurgery Vol. 57: 4, N9, 2005

2. Greenfield, JP, Boockvar, JA. Is there a Glioma Stem Cell? Science Times, Neurosurgery, Vol. 57: 6, N7, 2005

3. Greenfield, JP, Boockvar, JA. Fallibility of GBM cell lines overcome by use of tumor derived stem cell lines, Neurosurgery Vol 59: 2, N9 2006

4. Greenfield JP, Boockvar, JA. Activation of Early Glial Progenitors in Multiple Sclerosis Neurosurgery Vol 60: 6 N7 2007

5. Greenfield JP, Boockvar, JA. Repairing Damage within the Subventricular Zone Neurosurgery Vol 60: 4 N6 2007

6. Greenfield JP, Boockvar, JA. Neurocytoma is a Tumor of Adult Neuronal Progenitor Cells Neurosurgery Vol 60: 2, 8N9 2007

7. Greenfield JP, Boockvar, JA. Stem cell migration in a novel model to study pedeatric brain tumors. Neurosurgery. 63, 2008.

8. Greenfield JP, Cobb, WS, Lyden, D. Resisting Arrest: A switch from angiogenesis to vasculogenesis in recurrent malignant gliomas. The Journal of Clinical Investigation 1,2, 2010.

Meeting Abstracts

1. Greenfield JP, Seeger, M., Xu, H., Mazzarelli, L., Thinakaran, G., Wang, R., Sisodia, S. S., Greengard, P. and Gandy, S. (1997) Alzheimer’s β-amyloid Precursor Protein Metabolism in Saccharomyces cerevisiae and in cell-free system. 27th annual Meeting, Society for Neuroscience. New Orleans, LA.

2. Greenfield JP, Seeger, M., Xu, H., Wang, R., Greengard, P., and Gandy, S. (1998) Beta-amyloid precursor protein metabolism and Aß generation in Saccharomyces Cerevisiae. 6th International Conference on Alzheimer's Disease and Related Disorder. Amsterdam, The Netherlands.

3. Xu, H., Greenfield JP, Gouras, G. K., Vincent, B., Fried, G., Checler, F., Thinakaran, G., Sisodia, S. S., Wang, R., Greengard, P., and Gandy, S. (1998) Estrogen reduces neuronal generation of Alzheimer’s ß-amyloid peptides. 6th International Conference on Alzheimer's Disease and Related Disorder. Amsterdam, The Netherlands.

4. Gouras, G.K., Xu, H., Tsai, J., Greenfield JP, Naslund, J., Edgar, M., Wang, R., Buxbaum, J., Greengard, P., Gandy, S, and Relkin, N. (1998) Intracellular Aβ42 immunoreactivity in cultured neurons and brain. 6th International Conference on Alzheimer’s Disease and Related Disorder. Amsterdam, The Netherlands.

5. Greenfield JP, Gandy, S., Greengard, P., and Xu, H. (1999) Cell Biological Basis for the Anti-Amyloidogenic Effects of Estrogen. 29th Annual Meeting, Society for Neuroscience. Miami Beach, FL.

6. Xu, H., Greenfield JP, Gouras, G. K., and Greengard, P. (1999) Analysis of Optimal Intraorganellar Conditions for ß-amyloid Formation. 29th Annual Meeting, Society for Neuroscience. Miami Beach, FL.

7. Gouras, G. K., Tsai, J., Greenfield JP, Hai, B., Greengard, P., and Xu, H. (1999) Neuronal Aß Generation in Primary Cultures and Human Brain. 29th Annual Meeting, Society for Neuroscience, Miami Beach, FL.

8. Greenfield JP, Xu H, and Greengard P. (2000) Estrogen and Alzheimer’s Disease. Cornell Center for Aging Research and Clinical Care Aging Symposium. New York Hospital, New York, N.Y.

9. Greenfield JP, Gross R. S., Gouras, G. K., Leung, L., Rodriguez-Boulan, E., Kaasik, K., Greengard, P., and Xu, H. (2000) Molecular and cellular basis for the anti-amyloidogenic effects of estrogen. World Alzheimer Congress 2000; 7th International Conference on Alzheimer's Disease and Related Disorders. Washington, D.C.

10. Gouras, G. K., Gross, R. S., Netzer, W. J., Greenfield JP, Greengard, P., and Xu, H. (2000) Intracellular ß-amyloid with aging and Alzheimer’s Disease. World Alzheimer Congress 2000; 7th International Conference on Alzheimer's Disease and Related Disorders. Washington, D.C.

11. Cai DM, Thinakaran G, Greenfield JP, Gandy S, Greengard P, Sisodia SS, and Xu H. (2002) The Role of Presenilins in Regulating the Intracellular Trafficking and Metabolism of the -Amyloid Precursor Protein (APP). 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden.

12. Greenfield JP and Souweidane MM. (2005) Intraoperative Assessment of Third Ventriculostomy Success. AANS, Pediatrics Section, Orlando, Florida.

13. Greenfield JP and Souweidane MM. (2005) Cavernous Malformations in the Pediatric Population. CNS Annual Meeting, Boston, Massachusetts.

14. Greenfield JP and Schwartz TS (2005) Stereotactic Placement of Ommaya Reservoir Catheters. CNS Annual Meeting, Boston, Massachusetts.

15. Greenfield JP and Souweidane MM. (2006) Intraoperative Assessment of Third Ventriculostomy Success. AANS, San Francisco, CA.

16. Greenfield JP, Karampelis Y, Boockvar JA, Luther N, Souweidane MM. (2007) A Stem Cell-Based Model of Invasive Brain Stem Glioma. AANS, Pediatric Section, Miami Beach, FL.

17. Greenfield JP, Anand VK, Kacker A, Brown SM, Schwartz TH. (2007) Endoscopic, Endonasal, Transethmoidal, Transcribiform Approach to the Anterior Skull Base and Anterior Cranial Fossa. AANS, Washington, D.C.

18. Greenfield JP, Boockvar JA, Souweidane MM. (2008) A Stem Cell-Based Model of Brain Stem Glioma. ANNS, Chicago.

19. Greenfield JP, Cobb WS, Tsouris AJ, Schwartz TH (2008) Stereotactic Minimally Invasive Tubular Retractor System (METRx™) for Deep Brain Lesions, AANS, Chicago.

20. Allen BB, Chiu Y-L, Gerber LM, Ghajar J, Greenfield JP (2011) Age-Specific Cerebral Perfusion Pressure Thresholds and Mortality in Children and Adolescents with Severe Traumatic Brain Injury, AANS, Denver.

21. Greenfield JP. Endoscopic Endonasal Management of Pediatric Skull Base Pathology, Peds Section, AANS. Dallas, TX. Dec 4, 2011.

22. Huang Y., Rajjapa P, Greenfield JP. PDGF signaling pathway-dependant glioma vascularization mediated by oligodendritic precursor and tumor-associated macrophage. ASPN, Puerto Rico, Feb 1, 2012.

23. Lightner DD, Haque S, Souweidane MM, Yasmin Khakoo Y, Dunkel IJ, Gilheeney SW, Kramer K, Lyden DC. Wolden S, Greenfield JP, Kevin C. De Braganca1 Brainstem primitive neuroectodermal tumors mimicking diffuse intrinsic pontine gliomas. ISPNO, 2012 Toronto, Canada.

24. Rajappa P, Hoffman CE, Huang Y, Nishatori A, Kim JH, Silva B, Selgas H, Lyden DC, Greenfield JP. Glioma Exosomes Modulate Low Grade Glioma Angiogenesis-Peds Section Meeting, St. Louis, MO, November 2012.

25. Rajappa P, Cobb WS, Huang Y, Lyden DC. Bromberg J, Greenfield JP. JAK-1/2 Inhibition Impairs Bone Marrow Derived Cell Recruitment Preventing Low to High Grade Glioma Transformation-Society for Neuro Oncology Meeting Washington, DC. November 2012.

26. Hoffman CE, Badal K, Rajappa P, Huang Y, Cobb W, Lyden D, Greenfield JP. Role of Bone Marrow Derived Cells in the Tumor Microenvironment of Medulloblastoma. AANS Pediatric Section Meeting, St. Louis, MO. 2012. Recipient of the Kenneth Shulman Award.

27. Huang Y, Bromberg J, Lyden DC & Greenfield JP. Glioma Neo-Vascularization Mediated through Oligodendritic Precursor cells through PDGFR-alpha//PDGF-CC Signaling Axis AACR-Tumor Invasion & Metastasis Meeting, San Diego, CA. January 22, 2013.

28. Huang Y, Bromberg J, Lyden DC & Greenfield JP. Oligodendritic precursors mediate vascular remodeling by a PDGF-C dependent signaling pathway in gliomas Gordon Research Conferences - Vascular Cell Biology Ventura, CA. January 28, 2013.

29. Banu MA, Rathman A, McCrea HJ, Souweidane MM, Anand VK, Schwartz, TH, Greenfield, JP. Safety and Efficacy of Endonasal Endoscopic Corridors and Approaches for Pediatric Skull Base Lesions. AANS, New Orleans, LA, 2013.

30. McCrea H, Bander E, Venn R, Reiner A, Iorgulescu JB, Puchi L, Schaefer P, Cederquist G, Greenfield JP. Gross Total Resection and Supratentorial Location Significantly Improve Overall Survival in Pediatric Patients with High Grade Glioma, Peds Neuro-Oncology, Ft Lauderdale, FL, May 13, 2013.

31. McCrea HJ, Banu MA, Hoffman C, Njoku I, Greenfield JP, Souweidane MM. Late Failure in Endoscopic Third Ventriculostomy. 42nd Annual Meeting AANS/CNS Section on Pediatric Neurosurgery, Toronto, ON, 2013.

32. Huang Y, Hoffman C, Rajappa P, Cisse B, Greenfield JP. ID2/KDR regulated pro-malignant myeloid derived suppressor cells drive low-grade glioma transformation. 37th Annual Meeting of the American Society of Pediatric Neurosurgeons, Guanacaste, Costa Rica, Jan 30, 2014.

33. Rajappa P, Huang Y, Vartanian E, Pisapia D, Lyden D, Bromberg J, Greenfield JP. Jak 1/2 Inhibition Following Bone Marrow Transplantation Mitigates Cd11b+/GR1+ Mediated Low-Grade Glioma Neoangiogenesis, 20th Annual Society for Neuro-Oncology Meeting, Miami, FL, November 19, 2014.

34. Li S & Greenfield JP. Genetic and epigenetic tumor evolution in Gliomatosis Cerebri, 21st Annual Society for Neuro-Oncology Meeting, San Antonio, TX, November 17, 2015.

35. Morgenstern PF, Connors S, Greenfield JP. Image guidance for the placement of Ommaya reservoirs: A comparison of fluoroscopy and frameless stereotactic navigation in 145 patients. 84th Annual American Association of Neurological Surgeons Meeting, Chicago, IL, April 30, 2016.

36. McCrea HM, Knopman J, O’Connor A, Greenfield JP, Preliminary results of a Phase I/II Trial Of Super-Selective Intra-arterial Infusion Of Erbitux And Avastin For Treatment Of Relapsed/Refractory Intracranial Glioma In Patients Under 22 Years Of Age. AANS Section, Houston, TX Dec 8, 2017.

37. Rajappa P and Greenfield JP Precision sequencing algorithm for pediatric neuro-oncology CNS/AANS Joint Section for Tumors, Houston, Tx, Oct 9, 2018

Educational Background:

Amherst College, Amherst, MA, 1994
B.A., Neuroscience, Magna Cum Laude

Cornell University Graduate School of Med Science, New York, NY, 1999
Ph.D, Molecular and Cellular Neuroscience

Weill Cornell Medical College, New York, NY, 2002
M.D.


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