Charles B. Simone, II, MD, FASTRO, FACRO is Research Professor and Chief Medical Officer of the New York Proton Center and Full Member in the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center. He is an internationally recognized expert in proton therapy, reirradiation, stereotactic body radiation therapy, and innovative clinical trial strategies in thoracic oncology.

Dr. Simone was previous Chief of the Thoracic Oncology Service at the Hospital of the University of Pennsylvania, Director of the Penn Mesothelioma and Pleural Program, and Director of Clinical Research and Operations in Radiation Oncology at UPenn. He was then Medical Director of the Maryland Proton Treatment Center, and at UMaryland, he also served as Chair of the Clinical Research Committee for their Comprehensive Cancer Center, proton therapy Fellowship Director, and Director of the Stereotactic Radiation Therapy Program. He completed undergraduate and medical school at UPenn and radiation oncology residency at the National Cancer Institute (NCI), NIH, serving as chief resident. 

He is an NIH, National Science Foundation, and Department of Defense funded investigator who published >650 scientific articles/chapters, given >560 national/international scientific lectures, and is national Principal Investigator/Co-Chair of 8 NIH-funded cooperative group trials (NRG Oncology=5, SWOG=1, ECOG-ACRIN=1, PCG=1). He is a three-time Association of Residents in Radiation Oncology Educator of the Year Award winner. He is the Proton Collaborative Group (PCG) Board President. He Chairs: American Society for Radiation Oncology (ASTRO) Annual Meeting Scientific Committee Lung/Thoracic Track, ASTRO Lung Resource Panel Committee, ASTRO Blue Ribbon Lung Panel, NRG Oncology Particle Therapy Work Group, PCG Lung Committee, American Radium Society Appropriate Use Criteria Thoracic Committee, Particle Therapy Co-Operative Group Thoracic Subcommittee, American College of Radiation Oncology Scientific Program Committee, NCI/Radiosurgery Society SFRT and Flash Working Group, Varian FlashForward Consortium Scientific Committee, and Varian Proton Connect Users Group. He is Annals of Palliative Medicine Editor-in-Chief and on the Editorial Boards of Frontiers in Oncology, Translational Lung Cancer Research, Cancers, Journal of Thoracic Disease, Annals of Translational Medicine, and Therapeutic Radiology and Oncology, among others.