Doctor Profile

Caitlin E. Hoffman

Caitlin Hoffman

New York

New York (NY)

Contact Contact Caitlin E. Hoffman
T: 212-746-2363
F: 212-746-7729

Neurological Surgery
Doctor's practice has a pediatric specialty or subspecialty

Neurological Surgery


Dr. Hoffman is a board-certified neurosurgeon who specializes in the surgical treatment of epilepsy and craniofacial disorders. She also treats all pediatric neurosurgical disorders, including hydrocephalus, brain and spine tumors, intraventricular tumors, and Chiari malformations. Dr. Hoffman sees patients at NewYork-Presbyterian/Weill Cornell Medical Center, NewYork-Presbyterian Queens, and NewYork-Presbyterian Brooklyn Methodist, and performs surgery at New York Presbyterian/Weill Cornell Medical Center and Memorial Sloan Kettering. She works with a multi-institutional, comprehensive pediatric epilepsy program at all three campuses, with current research interests involving the use of focused ultrasound in the treatment of refractory epilepsy. Her craniofacial practice involves a multi-disciplinary craniofacial program that treats complex syndromic patients collaboratively. She utilizes both open and endoscopic approaches, and is currently involved in investigating the genomics of synostosis as it relates to outcomes.

In November 2019 Dr. Caitlin Hoffman performed the first-ever functional hemispherotomy in Tanzania on a four-year-old boy with intractable seizures. Dr. Hoffman was assisted by Dr. Whitney Parker, a Weill Cornell Medicine neurosurgical resident, as well as by Dr. Japhet Ngerageza, the patient’s attending neurosurgeon. The surgery was successful, and the little boy is now seizure free.

Dr. Hoffman is the co-director of the Multidisciplinary Craniofacial Program as well as the director of the Pediatric Epilepsy Surgery Program

Dr. Hoffman's administrative practice focuses on mentorship of under-served, underrepresented minority students interested in careers in medicine. She is currently developing a longitudinal mentorship tool in partnership with Mentoring in Medicine to increase matriculation and to help decrease healthcare disparities, and is a co-founder of the PrIMES Program. She is also involved in Global Neurosurgery initiatives in Tanzania, where in 2019 she performed the first-ever hemispherotomy for epilepsy in that East African nation.

Dr. Hoffman graduated summa cum laude from Columbia University, where she was elected to Phi Beta Kappa, before receiving her M.D. from Weill Cornell Medical College. She completed a neurosurgical residency and chief residency at New York-Presbyterian Hospital/Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center, then went on to complete advanced fellowship training in pediatric neurosurgery at the Hospital for Sick Kids in Toronto.

During her neurosurgical training, Dr. Hoffman was awarded the 2013 Distinguished Housestaff Award by NewYork-Presbyterian Hospital, the 2012 Dr. Kenneth Shulman Award by the AANS Pediatric Section, and the 2011 New York State Neurosurgical Society-Resident Research Award; in 2006 she was selected for membership in Alpha Omega Alpha, the medical honor society.

Dr. Hoffman has published academic papers in leading journals including Cancer Research, Nature Medicine, Neurosurgery, and Journal of Neurosurgery: Pediatrics on topics ranging from advances in minimally invasive treatment of craniofacial disorders to innovative approaches to refractory epilepsy. 

Published In:

New York Super Doctors 2023
New York Rising Stars 2022
New York Rising Stars 2021
New York Rising Stars 2020

About Caitlin Hoffman

Medical School: Cornell University, Joan & Sanford I. Weill Medical College

Graduation Year: 2007

Professional Webpage:

Honors and Awards:

AAMC Healthcare Executive Diversity and Inclusion Certificate, 2018
Tara and Victor Menezes Clinical Scholar in Neurological Surgery Weill Cornell Healthcare Leadership Fellowship, 2016-2017
Antigua Epilepsy Week Grant, November 6th – 9th, 2016
Distinguished House Staff Award, 2013
Dr. Kenneth Shulman Award – AANS Pediatric Section, 2012
New York State Neurological Society-Resident Research Award, 2011
Falcon Award, 2008
Ida Scudder Scholarship (Vellore, India), 2007
Dr. Connie Guion Scholarship, 2006-2007
Alpha Omega Alpha, 2006
Phi Beta Kappa, 2002

Special Licenses/Certifications:

American Board of Pediatric Neurological Surgery
American Board of Neurological Surgery

Professional Activity:

Victor and Tara Menezes Clinical Scholar Weill Cornell Medical College of Cornell University, New York, NY,
February 2017-January 2020, February 2020-January 2023

Assistant Member Affiliate, Neurological Surgery, Memorial Sloan Kettering Cancer Center
May 2016-present

Assistant Professor, Neurological Surgery, Weill Cornell Medicine
September 2015-present

Publications, Lectures and Presentations:

Articles in professional peer-reviewed journals

1. Karel-Bart Celie, MD, Thomas Imahiyerobo, MD, Caitlin Hoffman, MD. Surgical Management of Complex Syndromic Craniosynostosis: Experience with a Rare Genetic Variant and Literature Review. Journal of Craniofacial Surgery. August 2019. [Accepted for publication].
2. Birra Taha, Praneeth Sadda, Cristina Londono, Sunidhi Singh, Jeffrey Greenfield, Susan Pannullo, Caitlin Hoffman. Authorship Trends by Gender in Neurosurgery over the Past Two Decades. Journal of Neurosurgery. August 2019. [Submitted for publication].
3. Caitlin E Hoffman, MD, Benjamin R. Hartley, MD, MS, Cristina Londono BS, Lynne Holden, MD. PrIMES: A Targeted, Individualized Mentorship Solution to Closing the Healthcare Education Diversity Gap. Academic Medicine August 2019 [Submitted for publication].
4. Cheng D, Yuan M, Perera I, O’Connor, Evins A, Imahiyerobo T, Souweidane M, Hoffman C. Development of a Novel 3D printed Model of Surgical Simulation Training in Cranial Vault Remodeling. Journal of Neurosurgery: Pediatrics. July 2019 [Accepted for publication].
5. Radwanski RE, Winston G, Younus I, Eljalby M, Yuan M, Oh Y, Gucer SB, Hoffman CE, Stieg PE, Greenfield JP, Pannulo SC. Neurosurgery-Training Camp for Sub-internship Preparation: Lessons From the Inaugural Course. World Neursurg. 2019 Jul;127:e707-e716. Doi: 10.1016/j.wneu.2019.03.246
6. Grossman Tracy; Uribe-Cardenas Rafael, Radwanski Ryan, Souweidane Mark, Hoffman Caitlin. Fetal Arachnoid Cysts: Using prenatal imaging and need for pediatric neurosurgical intervention ot better understand their natural history and prognosis. Journal of Ultrasound Medicine. July 2019. [submitted for publication].
7. Franziska A. Schmidt MD, Sertac Kirnaz, MD, Christoph Wipplinger, MD, Claudia M. Kuzan-Fischer, MD, Roger Hartl, MD, Caitlin Hoffman, MD. Review of the Highlights from the Frist Annual Global Neurosurgery 2019: A Practical Symposium. World Neurosurgery July 2019. [Submitted for publication].
8. Parker W, Weidman E, Chazen JL, Sumit N, Uribe-Cardenas R, Kaplitt M, Hoffman CE,. Magnetic Resonance-Guided Focused Ultrasound for Ablation of Mesial Temporal Epilepsy Circuits: Modeling and Theoretical Feasibility of a Novel Non-Invasive Approach. Journal of Neurosurgery. 2019 Jun 14:1-8 [Epub ahead of print].
9. Celie Karel-Bart, Yuna Melissa, Cunniff Christopher, Bogue Jarrod, Hoffman Caitlin, Imahiyerobo, Thomas. Rapidly Progressive Multi-Sutural Craniosynostosis in a Patient with Jackson-Weiss Syndrome and a de novo FGFR2 Pathogenic Variant. The Cleft Palate-Craniofacial Journal 2019 May 23. Doi:10.1177/1055665619851642. [Epub ahead of print]
10. Hoffman CE, Yuan M, Boyke A, O’Connor A, Haussner T, Perera I, Souweidane MM. Impact of Advanced Practice Provider Directed Plagiocephaly Clinic for Neurosurgical Practices. Journal of Neurosurgery: Pediatrics. 2019 Mar 29:1-4. Doi: 10.3171/2019.1.PEDS18385 [Epub ahead of print]
11. Hartley B, Birnbaum C, Hoffman CE. Cavernous malformation hemorrhage due to trans-mural pressure alterations after cerebrospinal fluid diversion: a case report. Journal of Neurosurgery. March 2019 [submitted for publication]
12. Lopez M, Morrison K, Lee J, Hoffman CE, Souweidane MM, Ascherman JA. Calculated Blood Loss and Transfusion Requirements in Primary Open Repair of Craniosynostosis. Plast Reconstr Surg Glob Open 2019 Feb. 8;7(2):e2112. Doi: 10.1097/GOX.0000000000002112.
13. Copeland AE, Hoffman CE, Tsitouras V, Jeevan DS, Ho ES, Drake JM, Forrest CR. Clinical Significance of Venous Anomalies in Syndromic Craniosynostosis. Plast Reconstr Surg Glob Open. 2018 Jan. 18;6(1):e1613. Doi 10.1097/GOX.0000000000001613.
14. Janjua MB, Hoffman CE, Souweidane MM. Contemporary management and surveillance strategy after shunt or endoscopic third ventriculostomy procedures for hydrocephalus. J Clin Neurosci. 2017 Nov;45:18-23. doi: 10.1016/j.jocn.2017.004.
15. Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse JT, Pisapia DJ, Chan TA, Lyden D, Bromberg J, Greenfield JP. Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells. Clin Cancer Res. 2017 Jun 15;23(12):3109-3119. doi: 10.1158/1078-0432.CCR-16-1508.
16. Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, George E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May;127(5):1826-1838. doi: 10.1172/JCI86443.
17. Singh H, Essayed Wl, Deb S, Hoffman C, Schwartz TH. Minimally Invasive Robotic Laser Corpus Callosotomy: A Proof of Concept. Cureus. 2017 Feb 10;9(2):e1021 doi: 10.7759/cureus.1021
18. Peinado H, Alecˇković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502b.
19. Morgenstern PF, Hoffman CE. Successful Endoscopic Third Ventriculostomy in the Presence of an Intraventricular Developmental Venous Anomaly: Annals of Clinical Case Report. July 2016.
20. Hoffman CE, Ochi A, Snead OC 3rd, Widjaja E, Hawkins C, Tisdal M, Rutka JT. Rasmussen's encephalitis: advances in management and patient outcomes. Childs Nerv Syst. 2016 Apr;32(4):629-40. doi: 10.1007/s00381-015-2994-x.
21. Slater LA, Hoffman C, Drake J, Krings T. Pre-operative embolization of a choroid plexus carcinoma: review of the vascular anatomy. Childs Nerv Syst. 2016;32(3):541-5.
22. Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Ma Y, Tse K, Zeng T, Shumansky K, Roth AJ, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJ, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfield YS, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack IF, Hamilton RL, Li XN, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH Jr, Stearns DS, Massimi L, Schüller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DP, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischhack G, Tippelt S, Ra YS, Bailey S, Lindsey JC, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DT, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones SJ, Malkin D, Marra MA, Taylor MD. Divergent Clonal Selection Dominates Medulloblastoma At Recurrence. Nature. 2016 Jan 21;529(7586):351-7. doi: 10.1038/nature16478.
23. Morgenstern PF, Hoffman CE, Kocharian G, Singh R, Stieg PE, Souweidane MM. Postoperative imaging for detection of recurrent arteriovenous malformations in children. J Neurosurg Pediatr. 2015:1-7.
24. Xu R, McCrea HJ, Hoffman CE, Souweidane MM, Greenfield JP. The impact of endoscopic third ventriculostomy on shunt revision rate: a 14-year experience at a single institution. World Neurosurg. 2015 Sep;84(3):677-680.el. doi: 10.1016/j.wneu.2015.04.037.
25. Wang X, Dubuc AM, Ramaswamy V, Mack S, Gendoo DM, Remke M, Wu X, Garzia L, Luu B, Cavalli F, Peacock J, López B, Skowron P, Zagzag D, Lyden D, Hoffman C, Cho YJ, Eberhart C, MacDonald T, Li XN, Van Meter T, Northcott PA, Haibe-Kains B, Hawkins C, Rutka JT, Bouffet E, Pfister SM, Korshunov A, Taylor MD. Medulloblastoma subgroups remain stable across primary and metastatic compartments. Acta Neuropathol. 2015 Mar;129(3):449-57. doi: 10.1007/s00401-015-1389-0.
26. Huang Y, Hoffman C, Rajappa P, Kim JH, Hu W, Huse J et al. Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier. Cancer Res. 2014 Feb 15;74(4):1011-21. doi: 10.1158/00008-5472.CAN-13-1072.
27. Hoffman CE, Santillan A, Rotman L, Gobin YP, Souweidane MM. Complications of cerebral angiography in children younger than 3 years of age. J Neurosurg Pediatr. 2014 Apr;13(4):414-9. doi: 10.3171/2013.12.PEDS13172.
28. Hoffman CE, Savage N, Souweidane MM. The Significance of Cyst Remnants Following Endoscopic Colloid Cyst Resection: A Retrospective Clinical Case Series. Neurosurgery. 2013 Aug;73(2):233-7. doi: 10.1227/01.neu.0000430300.10338.71.
29. Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012 Jun;18(6):883-91. doi: 10.1038/nm2753.
30. Allen BB, Hoffman CE, Traube CS, Weinstein SL, Greenfield JP. Continuous Brain Tissue Oxygenation Monitoring in the Management of Pediatric Stroke. Neurocrit Care. 2011 Dec;15(3):529-36. doi: 10.1007/s12028-011-9531-x
31. Hoffman C, Riina HA, Stieg P, Allen B, Gobin YP, Santillan A, Souweidane M. Associated Aneurysms in Pediatric Arteriovenous Malformations and the Implications for Treatment. Neurosurgery. 2011 Aug;69(2):315-22. doi: 10.1227/NEU.0b013e31821524a1.
32. Chater-Cure G, Hoffman C, Knopman J, Rhee S, Souweidane MM. Endoscopy-assisted removal of periorbital inclusion cysts in children. J. Neurosurg Pediatr. 2011 Feb;7(2):161-4. doi: 10.3171/2010.11.PEDS10332.
33. Hoffman CE, Souweidane MM: Cerebrospinal fluid-related complications with Autologous Duraplasty and Arachnoid Sparing in Type I Chiari Malformation. Neurosurgery. 2008 Mar;62(3 Suppl 1):156-60. doi: 10.1227/
34. Souweidane MM, Hoffman CE, Schwartz TH. Transcavum interforniceal endoscopic surgery of the third ventricle. J Neurosurg Pediatrics. 2008;Oct;2(4):231-6. doi: 10.3171/PED.2008.2.10.231
35. Greenfield JP, Hoffman CE, Kuo E, Christos P, Souweidane MM. Intraoperative assessment of endoscopic third ventriculostomy success. J Neurosurg Pediatrics. 2008 Nov;2(5):298-303. doi: 10.3171/PED2008.2.11.298.
36. Ament JD, Hoffman C, Black PM. Idiopathic Intracranial Hypertension. Neurosurgery Quarterly. 2007;17(2):77-80.
37. Hoffman CE, Ament J, Black P. Meningioma and NF2: A review. Neurosurgery Quarterly, 2007.
38. Hoffman CE, Lis E, Wolden SJ, Souweidane MM. Symptomatic Chiari Type I Malformation After Radiation Therapy in an Infant: Case Report. Neurosurgery. 2007 Apr;60(4):E782.
39. Invited Review. Greenfield JP, Hoffman CE, Boockvar J. Tumor Stem Cells in Glioblastoma. Neurosurgery, 2006.
40. England H, Hoffman C, Hodgman T, Singh S, Homoud M, Weinstock J, Link M, Estes NA. Effectiveness of automated external defibrillators in high schools in greater Boston. Am J Cardiol. 2005 Jun 15;95(12):1484-6.
41. Marenco J, Hoffman CE, Wang P, Link M, Homoud M, Estes NA. Prediction and Prevention of Sudden Cardiac Death in the Athlete: Role of the Automatic External Defibrillator. Medicine and Sports, 2003.
42. Hoffman CE, Marenco J, Wang P, Link M, Homoud M, Estes NA. Public Access Defibrillation Programs: The Role of the Automatic External Defibrillator. Cardiovascular Reviews and Reports. 23(5):286-291, 2002.
43. Marenco J, Hoffman CE, Wang P, Link M, Homoud M, Estes NA. The Automatic External Defibrillator: Revolutionizing the Approach to the Treatment of Sudden Cardiac Death. The American Journal of Medicine and Sports, 2001.

1. Uribe R, Hoffman C. (They might also include the previous authors of the chapter). Mesial Temporal Sclerosis in Pediatric Epilepsy. In: Pediatric Epilepsy Surgery (Second Edition). Thieme Medical Publishers. Jallo G, Cataltepe O. (eds). In press.
2. Uribe R, Hoffman C. Multifocal epilepsy and multifocal resections. In: Pediatric Epilepsy Surgery (Second Edition). Thieme Medical Publishers. Jallo G, Cataltepe O. (eds). In press.
3. Amoashiy, Michael, Prajwal Rajappa, and Caitlin Hoffman. "Plexopathy, Brachial." Neurologic Differential Diagnosis: A Case-based Approach. Ed. Alan B. Ettinger and Deborah M. Weisbrot. N.P.: Cambridge UP, 2014. 612-22.
4. Greenfield JP, Cobb WS, Hoffman CE, Chen X, Rajappa P, Ihunna C, Huang Y, Lyden D. Bone Marrow Derived Cells Support Malignant Transformation of Low-Grade Glioma. Glioma-Exploring its Biology and Practical Relevance. InTeCH, Nov 2011.
5. Mariano GS, Fink ME, Hoffman C, Rosengart A. Intracranial Pressure: Monitoring and Management. Critical Care Medicine. Schmidt and Hall, 2011.

Educational Background:

B.A., Columbia University, New York, NY


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